Objective The objective of this meta‐analysis was to quantify the overall effects of gene
mutations in the leptin‐melanocortin pathway on short‐and long‐term weight loss after …

The leptin-melanocortin pathway (LMP) is an essential component of hypothalamic energy
balance regulation. Heterozygous variants in genes encoding for components of the LMP …

Background Mutations in the leptin-melanocortin pathway genes are known to cause
monogenic obesity. The prevalence of these gene mutations and their effect on weight loss …

Obesity is a major public health concern; despite evidence of high heritability, the genetic
causes of obesity remain unclear. In this study, we assessed the presence of mutations in …

Background Gene mutations in the leptin-melanocortin signaling cascade lead to
hyperphagia and severe early onset obesity. In most cases, multimodal conservative …

Introduction Heterozygous variants in the leptin-melanocortin pathway are associated with
obesity. However, their effect on the long-term outcomes after Roux-en-Y gastric bypass …

Background: Roux-en-Y gastric bypass surgery (RYGB) is among the few treatments that
can lead to type 2 diabetes (T2D) remission. Previously, it has been shown that carriers of …

Purpose Variants in the leptin-melanocortin pathway (LMP) are associated with severe
obesity. We evaluated weight loss of patients with or without heterozygous LMP variants …

Abstract Melanocortin-4 receptor gene (MC4R) variants are associated with obesity and
binge eating disorder (BED), whereas the more prevalent proopiomelanocortin (POMC) and …

Background Bariatric surgery is the most effective long-term treatment for morbid obesity,
reducing obesity-associated comorbidities. The purpose of the present study was to …