The exocytosis of death-inducing granzymes stored in the granules of cytotoxic lymphocytes
allows the immune system to rapidly eliminate intracellular pathogens and transformed cells …

Cytotoxic T lymphocyte (CTL)–induced death triggered by the granule exocytosis pathway
involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has …

A new form of intercellular signaling is described for lymphocyte granule-mediated
apoptosis. Christopher Froelich, Vishva Dixit and Xiaohe Yang propose that perforin delivers …

Granzymes are cell death‐inducing serine proteases released from cytotoxic granules of
cytotoxic T lymphocytes and natural killer cells during granule exocytosis in response to viral …

Perforin/granzyme-induced apoptosis is the main pathway used by cytotoxic lymphocytes to
eliminate virus-infected or transformed cells. Studies in gene-disrupted mice indicate that …

Cell death is mediated by cytotoxic lymphocytes through various granule serine proteases
released with perforin. The unique protease activity, restricted expression, and distinct gene …

When a cytotoxic lymphocyte binds to an antigenic cell, there is a reorientation of the Golgi
apparatus and a directed exocytosis of cytoplasmic granules toward the offending cell. In the …

Recent advances in our understanding of cytolytic effector mechanisms include the partial
characterization of caspase-independent apoptotic pathways triggered by granzymes, a …

Granzyme (gzm) B–deficient cytotoxic lymphocytes (CTL) have a severe defect in the rapid
induction of target cell apoptosis that is almost completely corrected by prolonged incubation …

Cytotoxic lymphocytes rapidly respond and destroy both malignant cells and cells infected
with intracellular pathogens. One mechanism, known as granule exocytosis, employs the …