First-line and maintenance therapy for ovarian cancer: current status and future directions

A González-Martín, L Sánchez-Lorenzo, R Bratos… - Drugs, 2014 - Springer
Paclitaxel and carboplatin combination chemotherapy has remained the standard of care in
the frontline therapy of advanced epithelial ovarian carcinoma during the last decade …

First-line systemic treatment of ovarian cancer: a critical review of available evidence and expectations for future directions

O Metzger-Filho, C Moulin… - Current opinion in …, 2010 - journals.lww.com
The standard first-line chemotherapy in EOC is based on the doublet carboplatin plus
paclitaxel. It may be possible to improve the efficacy of treatment by means of a more …

Ovarian cancer treatment: what is new

A Poveda - International Journal of Gynecologic Cancer, 2003 - ijgc.bmj.com
Ovarian cancer is still the fourth cause of death by cancer among women and the most fatal
among gynecological tumors. The purpose of this symposium is, year after year, to report …

Ovarian cancer

BT Hennessy, RL Coleman, M Markman - The lancet, 2009 - thelancet.com
The standard initial management of epithelial ovarian cancer consists of surgical staging,
operative tumour debulking including total abdominal hysterectomy and bilateral salpingo …

Targeting the hallmarks of ovarian cancer: The big picture

M Petrillo, C Nero, G Amadio, D Gallo, A Fagotti… - Gynecologic …, 2016 - Elsevier
Objective As a result of relevant achievements in the field of translational research, several
active drugs and multiple biological targets are available in ovarian cancer (OC). In this …

Novel therapeutic agents in ovarian cancer

R Agarwal, M Linch, SB Kaye - European Journal of Surgical Oncology …, 2006 - Elsevier
AIMS: Epithelial ovarian cancer is responsible for 4% of all cancer deaths in women, and the
five-year overall survival of patients with advanced disease is 30–40%. Treatment currently …

[HTML][HTML] Updates and new options in advanced epithelial ovarian cancer treatment

KC Kurnit, GF Fleming, E Lengyel - Obstetrics & Gynecology, 2021 - journals.lww.com
Financial Disclosure Ernst Lengyel disclosed that money was paid to his institution from
AbbVie (funding preclinical studies), NCI (RO1 grants), and the Ovarian Cancer Research …

Ovarian cancer: progress and continuing controversies in management

C Moss, SB Kaye - European Journal of Cancer, 2002 - Elsevier
Ovarian cancer is the most lethal of the gynaecological cancers, affecting approximately 1 in
75 women in the developed world. In most cases (> 75%), the disease is disseminated …

Use of targeted therapeutics in epithelial ovarian cancer: a review of current literature and future directions

MH Vetter, JL Hays - Clinical therapeutics, 2018 - Elsevier
Purpose Epithelial ovarian cancer (EOC) is the leading cause of gynecologic cancer death
in the United States. Most patients will ultimately fail platinum-based chemotherapy and …

[HTML][HTML] Phase II study of bevacizumab with liposomal doxorubicin for patients with platinum-and taxane-resistant ovarian cancer

CF Verschraegen, S Czok, CY Muller, L Boyd, SJ Lee… - Annals of oncology, 2012 - Elsevier
Background Suppression of neoangiogenesis and pegylated liposomal doxorubicin (PLD)
each contribute to the management of platinum-resistant/refractory ovarian cancer. The aim …