Human multiple myeloma tumor cell lines (HMCLs) have been a cornerstone of research in
multiple myeloma (MM) and have helped to shape our understanding of molecular …

Simple Summary Multiple myeloma (MM) is the second most common hematological
neoplasia with a high incidence in elderly populations. The disease is characterized by a …

Multiple Myeloma (MM) is a haematological malignancy characterised by the clonal
expansion of plasma cells (PC s) within the bone marrow. Despite advances in therapy, MM …

The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory
agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed …

Background: Human multiple myeloma (MM) cell lines (HMCLs) have been widely used to
understand the molecular processes that drive MM biology. Epigenetic modifications are …

Deciphering genomic architecture is key to identifying novel disease drivers and
understanding the mechanisms underlying myeloma initiation and progression. In this work …

PURPOSE Multiple myeloma (MM) is accompanied by heterogeneous somatic alterations.
The overall goal of this study was to describe the genomic landscape of myeloma using …

Cancer-causing mutations disrupt coordinated, precise programs of gene expression that
govern cell growth and differentiation. Microarray-based gene-expression profiling (GEP) is …

Background Human myeloma cell lines (HMCLs) are widely used for their representation of
primary myeloma cells because they cover patient diversity, although not fully. Their genetic …

Multiple myeloma (MM) is the second most common hematologic malignancy encountered
among patients in the United States. The last decade has seen incremental improvements in …