1 The effects of SR 33589 and amiodarone on the cardiac β‐adrenoceptor were studied in
vitro and after chronic treatment by means of [125I]‐(−)− iodocyanopindolol ([125I]‐(−) …

We have assessed the ability of amiodarone and the new amiodarone-like antiarrhythmic
agent, SR 33589 (N, N-dibutyl-3-[4-((2-butyl-5-methylsulphonamido) benzofuran-3-yl …

1 Adrenaline‐induced arrhythmias in anaesthetized dogs respired with halothane were
attenuated in 3 groups of 6 dogs by either UK‐52046, 3.8±1.4 μgkg− 1 (mean±se mean) …

Abstract β-Antiadrenergic properties are part of the pharmacological characteristics of
amiodarone. In the present study, the action of amiodarone on rat-heart β-adrenoceptors …

1 In order to characterize the α1‐adrenoceptor subtypes mediating positive inotropic effects
of adrenaline (in the presence of propranolol) in rat right ventricular strips and the Ca2+ …

1 The relative proportions of β1 and β2‐adrenoceptors were determined by radioligand
binding studies in three different rat myocardial preparations: membranes prepared from rat …

1 It was examined by means of BMY 7378, a selective antagonist of α1D‐adrenoceptors,
whether α1D‐adrenoceptors contribute to the regulation of myocardial contractility and …

Abstract 1 [3H]-prazosin binds specifically to a single class of alpha-adrenoceptors in rat
cardiac membranes (KD25 degrees C= 0.2 nM). 2 That these receptors are of the alpha 1 …

The potencies as β-adrenoceptor blockers of KL 1006 (the N-isopropyl analogue of
bupranolol), pindolol, propranolol and carazolol were compared with potencies of their …

Hyperthyroidism is associated with elevation of heart cells sensitivity to catecholamines. We
demonstrated that T 3 (10− 8 M) increased (30%) the number of β-adrenoceptors in intact …