Molecular mechanism of action and selectivity of sodium ch annel blocker insecticides
Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides that
are represented by two commercially registered compounds, indoxacarb and …
are represented by two commercially registered compounds, indoxacarb and …
Mechanisms of action of insecticides on ligand-gated ion channels
M Ihara - Journal of Pesticide Science, 2007 - jstage.jst.go.jp
Ligand-gated ion channels (LGICs) mediate fast synaptic neurotransmission and are
important targets for insecticides. Thus, the actions of several insecticides have been …
important targets for insecticides. Thus, the actions of several insecticides have been …
Pyrethroids in an AlphaFold2 model of the insect sodium channel
BS Zhorov, K Dong - Insects, 2022 - mdpi.com
Simple Summary Pyrethroids are a major class of insecticides for controlling arthropod pests
and human disease transmitting vectors. Resistance to pyrethroid insecticides presents a …
and human disease transmitting vectors. Resistance to pyrethroid insecticides presents a …
Functional and evolutionary consequences of pyrethroid resistance mutations in S6 transmembrane segments of a voltage-gated sodium channel
Pyrethroids are a class of voltage-dependent sodium channel modifiers widely used as
insecticides for control of disease vectors and agricultural pests. Many insect populations …
insecticides for control of disease vectors and agricultural pests. Many insect populations …
Ion channels and G protein-coupled receptors as targets for invertebrate pest control: From past challenges to practical insecticides
Y Ozoe - Bioscience, Biotechnology, and Biochemistry, 2021 - academic.oup.com
In the late 1970s, we discovered that toxic bicyclic phosphates inhibit the generation of
miniature inhibitory junction potentials, implying their antagonism of γ-aminobutyric acid …
miniature inhibitory junction potentials, implying their antagonism of γ-aminobutyric acid …
Sodium channel genes and their differential genotypes at the L-to-F kdr locus in the mosquito Culex quinquefasciatus
The para-type sodium channel in insects is the primary target of pyrethroid and DDT
insecticides. However, modifications in the target protein structure such as point mutations or …
insecticides. However, modifications in the target protein structure such as point mutations or …
Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons
Pyrethroid insecticides bind to voltage-gated sodium channels (VGSCs) and modify their
gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to …
gating kinetics, thereby disrupting neuronal function. Pyrethroids have also been reported to …
Potent actions of the pyrethroid insecticides cismethrin and cypermethrin on rat tetrodotoxin-resistant peripheral nerve (SNS/PN3) sodium channels expressed in …
TJ Smith, DM Soderlund - Pesticide Biochemistry and Physiology, 2001 - Elsevier
The rat peripheral nerve tetrodotoxin (TTX)-resistant voltage-sensitive sodium channel
(designated SNS/PN3) was expressed in Xenopus laevis oocytes, and the responses of the …
(designated SNS/PN3) was expressed in Xenopus laevis oocytes, and the responses of the …
The modes of action of ion-channel-targeting neurotoxic insecticides: lessons from structural biology
Insecticides are indispensable tools for plant protection in modern agriculture. Despite
having highly heterogeneous structures, many neurotoxic insecticides use similar principles …
having highly heterogeneous structures, many neurotoxic insecticides use similar principles …