Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Alzheimer's disease (AD) is a neurodegenerative disorder, characterized by a progressive
loss of cognitive function. Despite considerable progress, a complete description of the …

Introduction Despite the extensive mechanistic and pathological characterization of the
amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which numerous
mouse models have been generated. In both AD patients and mouse models, there is …

Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Alzheimer's disease (AD) is characterised by progressive cognitive impairment with
neuropsychiatric symptoms such as anomalous motor behaviour, depression, anxiety …

Alzheimer's disease (AD) is the most common form of dementia. At the diagnostic stage, the
AD brain is characterized by the accumulation of extracellular amyloid plaques, intracellular …

2. Objectives In this review we first provide an overview of the transgenic mice proposed to
recapitulate facets of the AD clinical phenotype, with a brief description of molecular …

Alzheimer's disease (AD) is not only characterized by cognitive decline and
neuropathological changes, but also by non-cognitive behavioral symptoms like …