Genetic analysis of adiponectin and obesity in Hispanic families: the IRAS Family Study

BS Sutton, S Weinert, CD Langefeld, AH Williams… - Human genetics, 2005 - Springer
Adiponectin, coded for by the APM1 gene, is a novel adipocyte-derived hormone implicated
in energy homeostasis and obesity. Several genetic studies have observed evidence of …

A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

J Fredriksson, E Carlsson, M Orho-Melander… - International journal of …, 2006 - nature.com
Objective: Reduced serum adiponectin levels have been found in obesity and type 2
diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 …

[HTML][HTML] The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians

V Mackevics, IM Heid, SA Wagner, P Cip… - European Journal of …, 2006 - nature.com
Low concentrations of adiponectin, the protein product of the APM1 gene, have been
reported to be associated with obesity and insulin resistance. However, contrasting results …

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels …

F Vasseur, N Helbecque, C Dina… - Human molecular …, 2002 - academic.oup.com
Abstract Adiponectin (ACRP30), an adipocyte-secreted protein encoded by the APM1 gene,
is known to modulate insulin sensitivity and glucose homeostasis, those effects protecting …

A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome

C Menzaghi, T Ercolino, R Di Paola, AH Berg… - Diabetes, 2002 - Am Diabetes Assoc
Adiponectin is a protein secreted by adipocytes that modulates insulin action. To assess
whether variants of this gene contribute to the prevalence of insulin resistance in …

Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study

X Guo, MF Saad, CD Langefeld, AH Williams, J Cui… - Diabetes, 2006 - Am Diabetes Assoc
Adiponectin (APM1) is an adipocyte-derived peptide that contributes to glucose, lipid, and
energy homeostasis. We assessed the genetic basis of plasma adiponectin in Hispanic …

[HTML][HTML] Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly

WS Yang, YC Yang, CL Chen, IL Wu, JY Lu… - The American journal of …, 2007 - Elsevier
Background: Genetic variations of the human adiponectin gene are associated with
metabolic phenotypes, including obesity, insulin sensitivity, and diabetes. However, these …

[HTML][HTML] Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men

MT Berthier, A Houde, M Côté, AM Paradis… - Journal of lipid …, 2005 - ASBMB
The aim of this study was first to examine the relationships between adiponectin gene
(Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and …

An SNP in the adiponectin gene is associated with decreased serum adiponectin levels and risk for impaired glucose tolerance

JL González‐Sánchez, CA Zabena… - Obesity …, 2005 - Wiley Online Library
Adiponectin is a plasma protein produced by the adipose tissue. Hypoadiponectinemia has
been associated with insulin resistance and several components of the metabolic syndrome …

Molecular basis of a linkage peak: exome sequencing and family-based analysis identify a rare genetic variant in the ADIPOQ gene in the IRAS Family Study

DW Bowden, SS An, ND Palmer… - Human molecular …, 2010 - academic.oup.com
Family-based linkage analysis has been a powerful tool for identification of genes
contributing to traits with monogenic patterns of inheritance. These approaches have been …