Numerous instances can be seen in evolution in which protein quaternary structures have
diverged while the sequences of the building blocks have remained fairly conserved …

Molecular systems with coincident cyclic and superhelical symmetry axes have considerable
advantages for materials design as they can be readily lengthened or shortened by …

We describe a model for the design of synthetic α-helical peptides that are competent for self-
assembly into structurally defined supramolecular fibrils on the basis of architectural features …

Cavities and clefts are frequently important sites of interaction between natural enzymes or
receptors and their corresponding substrate or ligand molecules and exemplify the types of …

The rational design of peptides that fold to form discrete nanoscale objects, and/or self-
assemble into nanostructured materials is an exciting challenge. Such efforts test and …

The exquisite structure-function correlations observed in filamentous protein assemblies
provide a paradigm for the design of synthetic peptide-based nanomaterials. However, the …

Design of a structurally defined helical assembly is described that involves recoding of the
amino acid sequence of peptide GCN4-pAA. In solution and the crystalline state, GCN4-pAA …

Inspired by the key role of super-helical motifs in molecular self-organization, several
tandem heptad repeat peptides were used as building blocks to form well-ordered …

Tandem repeat proteins exhibit native designability and represent potentially useful
scaffolds for the construction of synthetic biomimetic assemblies. We have designed 2 …

Protein design studies using coiled coils have illustrated the potential of engineering simple
peptides to self-associate into polymers and networks. Although basic aspects of self …