Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

L He, X Lin, Y Wang, C Abraham, C Sou, T Ngo… - Science …, 2021 - science.org
Vaccination against SARS-CoV-2 provides an effective tool to combat the COVID-19
pandemic. Here, we combined antigen optimization and nanoparticle display to develop …

Subunit nanovaccine with potent cellular and mucosal immunity for COVID-19

L Liu, Z Liu, H Chen, H Liu, Q Gao, F Cong… - ACS applied bio …, 2020 - ACS Publications
To combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic,
we formulated the S1 subunit of the virus with two adjuvants, amphiphilic adjuvant …

The investigation of mRNA vaccines formulated in liposomes administrated in multiple routes against SARS-CoV-2

H Huang, C Zhang, S Yang, W Xiao, Q Zheng… - Journal of Controlled …, 2021 - Elsevier
COVID-19 pandemic has resulted in an unprecedented global public health crisis. It is
obvious that SARS-CoV-2 vaccine is needed to control the global COVID-19 public health …

[HTML][HTML] Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 …

J Zang, Y Zhu, Y Zhou, C Gu, Y Yi, S Wang, S Xu, G Hu… - Cell Discovery, 2021 - nature.com
Massive production of efficacious SARS-CoV-2 vaccines is essential for controlling the
ongoing COVID-19 pandemic. We report here the preclinical development of yeast …

A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential

J Gai, L Ma, G Li, M Zhu, P Qiao, X Li, H Zhang… - MedComm, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has become a serious
burden on global public health. Although therapeutic drugs against COVID‐19 have been …

[HTML][HTML] Recombinant COVID-19 vaccine based on recombinant RBD/Nucleoprotein and saponin adjuvant induces long-lasting neutralizing antibodies and cellular …

A Ghaemi, P Roshani Asl, H Zargaran… - Frontiers in …, 2022 - frontiersin.org
SARS-CoV-2 has caused a global pandemic, infecting millions of people. An effective
preventive vaccine against this virus is urgently needed. Here, we designed and developed …

[HTML][HTML] Production and Characterization of Nucleocapsid and RBD Cocktail Antigens of SARS-CoV-2 in Nicotiana benthamiana Plant as a Vaccine Candidate …

T Mamedov, D Yuksel, M Ilgın, I Gürbüzaslan, B Gulec… - Vaccines, 2021 - mdpi.com
The COVID-19 pandemic has put global public health at high risk, rapidly spreading around
the world. Although several COVID-19 vaccines are available for mass immunization, the …

[HTML][HTML] Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA. 1, BA. 2, and BA. 4/5 and diverse sarbecoviruses

M Li, Y Ren, ZQ Aw, B Chen, Z Yang, Y Lei… - Nature …, 2022 - nature.com
Abstract As SARS-CoV-2 Omicron and other variants of concern (VOCs) continue spreading
worldwide, development of antibodies and vaccines to confer broad and protective activity is …

A vaccine delivery system promotes strong immune responses against SARS‐CoV‐2 variants

Z Lei, L Zhu, P Pan, Z Ruan, Y Gu, X Xia… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Global coronavirus disease 2019 (COVID‐19) pandemics highlight the need of
developing vaccines with universal and durable protection against emerging SARS‐CoV‐2 …

Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2

Y Xiang, S Nambulli, Z Xiao, H Liu, Z Sang, WP Duprex… - Science, 2020 - science.org
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …