NF-κB transcription factor induces drug resistance through MDR1 expression in cancer cells
The ubiquitous NF-κB transcription factor has been reported to inhibit apoptosis and to
induce drug resistance in cancer cells. Drug resistance is the major reason for cancer …
induce drug resistance in cancer cells. Drug resistance is the major reason for cancer …
Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity
C Freiburghaus, VK Emruli, A Johansson… - BMC cancer, 2018 - Springer
Background The addition of high-dose cytarabine to the treatment of mantle cell lymphoma
(MCL) has significantly prolonged survival of patients, but relapses are common and are …
(MCL) has significantly prolonged survival of patients, but relapses are common and are …
Oroxylin a reverses multi‐drug resistance of human hepatoma BEL7402/5‐FU cells via downregulation of P‐glycoprotein expression by inhibiting NF‐κB signaling …
HY Yang, L Zhao, Z Yang, Q Zhao… - Molecular …, 2012 - Wiley Online Library
In this study, oroxylin A showed strong reversal potency in BEL7402/5‐FU cells and the
reversal fold (RF) reached 4.69. Simultaneously, rhodamine‐123 accumulation assay and …
reversal fold (RF) reached 4.69. Simultaneously, rhodamine‐123 accumulation assay and …
PI3K/Akt inhibition modulates multidrug resistance and activates NF-κB in murine lymphoma cell lines
Upregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway has been described in
some tumors related to multidrug resistance (MDR). The aim of this work was to analyze the …
some tumors related to multidrug resistance (MDR). The aim of this work was to analyze the …
Reversal of multidrug resistance of human hepatocellular carcinoma cells by wild-type p53 gene and related mechanisms
XD Gai, GL Li, JZ Huang, HJ Xue… - Ai Zheng= Aizheng …, 2006 - europepmc.org
Methods The eukaryotic expression plasmid pCR 3.1-p53 was constructed and transfected
into human HCC cell line Bel-7402. Proliferation and chemosensitivity of Bel-7402 cells to …
into human HCC cell line Bel-7402. Proliferation and chemosensitivity of Bel-7402 cells to …
Differential bortezomib sensitivity in head and neck cancer lines corresponds to proteasome, nuclear factor-κB and activator protein-1 related mechanisms
Z Chen, JL Ricker, PS Malhotra, L Nottingham… - Molecular cancer …, 2008 - AACR
Head and neck squamous cell carcinomas (HNSCC) exhibit constitutive activation of
transcription factors nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), which are …
transcription factors nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), which are …
Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast …
X Lin, X Zhang, Q Wang, J Li, P Zhang, M Zhao, X Li - Neoplasma, 2012 - europepmc.org
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment
to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been …
to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been …
Reversal effect of PI3-K inhibitor LY294002 on P-glycoprotein-mediated multidrug resistance of human leukemia cell line K562/DNR and gastric cancer cell line …
Y Zhang, XJ Qu, YP Liu, XH Yang, KZ Hou… - Ai Zheng= Aizheng …, 2009 - europepmc.org
Methods The cells were divided into simple drug-treated groups and LY294002 pretreated
groups: the former groups received treatment of daunorubicin (DNR), adriamycin (ADR) …
groups: the former groups received treatment of daunorubicin (DNR), adriamycin (ADR) …
Proteasome-based mechanisms of intrinsic and acquired bortezomib resistance in non-small cell lung cancer
LHAM de Wilt, G Jansen, YG Assaraf… - Biochemical …, 2012 - Elsevier
The proteasome inhibitor bortezomib, registered for Multiple Myeloma treatment, is currently
explored for activity in solid tumors including non-small cell lung cancer (NSCLC). Here we …
explored for activity in solid tumors including non-small cell lung cancer (NSCLC). Here we …
Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones
L Contreras, RI Calderon, A Varela-Ramirez… - Cellular Oncology, 2018 - Springer
Purpose Previously, compounds containing a piperidone structure have been shown to be
highly cytotoxic to cancer cells. Recently, we found that the piperidone compound P2 …
highly cytotoxic to cancer cells. Recently, we found that the piperidone compound P2 …