Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors
Uridine adenosine tetraphosphate (Up4A) has been identified as an endothelium-derived
contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary …
contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary …
Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infarct remodeled myocardium is due to reduced P1 receptor activation
Z Zhou, D de Wijs-Meijler, I Lankhuizen… - Pharmacological …, 2013 - Elsevier
We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) exerts a potent
vasodilator effect in the healthy porcine coronary vasculature. Since the coronary …
vasodilator effect in the healthy porcine coronary vasculature. Since the coronary …
[HTML][HTML] Uridine adenosine tetraphosphate-induced coronary relaxation is blunted in swine with pressure overload: a role for vasoconstrictor prostanoids
Z Zhou, IM Lankhuizen, HM Van Beusekom… - Frontiers in …, 2018 - frontiersin.org
Plasma levels of the vasoactive substance uridine adenosine tetraphosphate (Up4A) are
elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in …
elevated in hypertensive patients and Up4A-induced vascular contraction is exacerbated in …
Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: an update
Z Zhou, T Matsumoto, V Jankowski, J Pernow… - Pharmacological …, 2019 - Elsevier
Uridine adenosine tetraphosphate (Up 4 A), biosynthesized by activation of vascular
endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium …
endothelial growth factor receptor (VEGFR) 2, was initially identified as a potent endothelium …
Uridine adenosine tetraphosphate acts as a proangiogenic factor in vitro through purinergic P2Y receptors
Z Zhou, I Chrifi, Y Xu, J Pernow… - American Journal …, 2016 - journals.physiology.org
Uridine adenosine tetraphosphate (Up4A), a dinucleotide, exerts vascular influence via
purinergic receptors (PR). We investigated the effects of Up4A on angiogenesis and the …
purinergic receptors (PR). We investigated the effects of Up4A on angiogenesis and the …
Uridine adenosine tetraphosphate induces contraction and relaxation in rat aorta
AE Linder, M Tumbri, FFP Linder, RC Webb… - Vascular …, 2008 - Elsevier
Uridine adenosine tetraphosphate (Up4A) has been recently reported as an endothelium-
derived vasoconstrictor and plasma levels of this dinucleotide are increased in juvenile …
derived vasoconstrictor and plasma levels of this dinucleotide are increased in juvenile …
[HTML][HTML] Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation
C Sun, T Jiao, D Merkus, DJ Duncker… - Journal of …, 2019 - Elsevier
Activation of both adenosine A 2A and A 2B receptors (A 2B R) contributes to coronary
vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) is …
vasodilation. We previously demonstrated that uridine adenosine tetraphosphate (Up 4 A) is …
[HTML][HTML] Identification and characterization of adenosine 5′-tetraphosphate in human myocardial tissue
T Westhoff, J Jankowski, S Schmidt, J Luo… - Journal of Biological …, 2003 - ASBMB
Endocrine functions of the human heart have been studied extensively. Only recently,
nucleotidergic mechanisms have been studied in detail. Therefore, an isolation strategy was …
nucleotidergic mechanisms have been studied in detail. Therefore, an isolation strategy was …
Evidence for the expression of multiple uracil nucleotide‐stimulated P2 receptors coupled to smooth muscle contraction in porcine isolated arteries
SJ Rayment, ML Latif, V Ralevic… - British journal of …, 2007 - Wiley Online Library
Background and purpose: The uracil nucleotides UDP and UTP have been reported to
activate P2Y2, P2Y4 and P2Y6 receptors to cause vasoconstriction. We have performed a …
activate P2Y2, P2Y4 and P2Y6 receptors to cause vasoconstriction. We have performed a …
Uridine adenosine tetraphosphate-induced contraction is increased in renal but not pulmonary arteries from DOCA-salt hypertensive rats
T Matsumoto, RC Tostes… - American Journal of …, 2011 - journals.physiology.org
Uridine adenosine tetraphosphate (Up4A) was reported as a novel endothelium-derived
contracting factor. Up4A contains both purine and pyrimidine moieties, which activate …
contracting factor. Up4A contains both purine and pyrimidine moieties, which activate …