Mortality risk stratification by combining BRAF V600E and TERT promoter mutations in papillary thyroid cancer: genetic duet of BRAF and TERT promoter mutations in …

R Liu, J Bishop, G Zhu, T Zhang, PW Ladenson… - JAMA …, 2017 - jamanetwork.com
Importance BRAF V600E andTERTpromoter mutations can coexist in papillary thyroid
cancer (PTC). This genetic duet was indicated to be involved in the aggressiveness of PTC …

Molecular markers involved in tumorigenesis of thyroid carcinoma: focus on aggressive histotypes

GC Penna, F Vaisman, M Vaisman… - … and genome research, 2017 - karger.com
Thyroid cancer derived from follicular cells (TCDFC) comprises well-differentiated (papillary
and follicular) carcinoma, poorly differentiated carcinoma, and anaplastic carcinoma …

Update on fundamental mechanisms of thyroid cancer

A Prete, P Borges de Souza, S Censi… - Frontiers in …, 2020 - frontiersin.org
The incidence of thyroid cancer (TC) has increased worldwide over the past four decades.
TC is divided into three main histological types: differentiated (papillary and follicular TC) …

[PDF][PDF] Molecular pathology of differentiated thyroid cancer

A Greco, MG Borrello, C Miranda… - Quarterly Journal of …, 2009 - researchgate.net
Thyroid cancer is the most common endocrine malignancy; it accounts for approximately 1%
of all new case of cancer each year, and its incidence has increased significantly over the …

TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors

M Matsuse, T Yabuta, V Saenko, M Hirokawa… - Scientific reports, 2017 - nature.com
Although most papillary thyroid carcinomas (PTCs) have a good prognosis, a small but
certain fraction shows aggressive behavior. Therefore, a novel and well-performing …

Challenging Dogma in Thyroid Cancer Molecular Genetics—Role of RET/PTC and BRAF in Tumor Initiation

JA Fagin - The Journal of Clinical Endocrinology & Metabolism, 2004 - academic.oup.com
RET/PTC oncogenes are believed to play an important role in the pathogenesis of a
significant subset of papillary carcinomas of the thyroid (PTC), in particular those arising …

ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome

C Tavares, M Melo… - European journal of …, 2016 - academic.oup.com
Genetic predictors of outcome are reviewed in the context of a disease–cancer–that can be
(too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has …

Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis

MN Nikiforova, YE Nikiforov - Expert review of molecular …, 2008 - Taylor & Francis
Thyroid cancer is the most common malignant tumor of the endocrine system and accounts
for approximately 1% of all newly diagnosed cancer cases. The most frequent type of thyroid …

BRAF mutations in thyroid cancer

RS Scheffel, JM Dora, AL Maia - Current Opinion in Oncology, 2022 - journals.lww.com
The impact of BRAF mutations on the clinical outcomes of PTC remains debatable. In ATCs,
in turn, BRAF mutations identify patients eligible for targeted therapy, which is now …

Molecular analysis of thyroid tumors

F Bhaijee, YE Nikiforov - Endocrine pathology, 2011 - Springer
Thyroid cancer is the most common endocrine malignancy, and its incidence is rising in the
USA and other countries. Papillary and follicular thyroid carcinomas are the two most …