The properties of synthetic peptides, including potency, stability, and bioavailability, are
strongly influenced by modification of the peptide chain termini. Unfortunately, generally …

The rising demand for regioselective protein modifications in chemical biology and
pharmaceutical manufacturing has fueled efforts to develop diverse techniques that …

Enzymes' machinery has been an inspiration for chemists. Peptides are vital players in the
origin of life, being ancestors of complex enzymes. Even short peptides that are simple in …

Many stereoselective peptide catalysts have been established. They consist, like nature's
catalysts, of amino acids but have significantly lower molecular weights than enzymes …

C-Terminal residues play a pivotal role in dictating the structure and functions of proteins.
Herein, we report a mild, efficient, chemoselective, and site-selective chemical method that …

In contrast to large proteins, small peptide catalysts typically display limited specificity for
small molecule substrates. This is presumably a result of the limited opportunities small …

A mild and efficient method for the conversion of C-terminal esters of side-chain protected
peptides into an amide function via enzyme-catalysed ammonolysis in organic media with …

A novel strategy in kinetically controlled enzymatic peptide synthesis is described. Various
amino acid derivatives with charged, highly solubilizing Nα-protecting groups were prepared …

The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding
the emergence of life. Building on our recent discovery that thiols catalyze the ligation of …

This article reports on the design and characteristics of substrate mimetics in protease-
catalyzed reactions. Firstly, the basis of protease-catalyzed peptide synthesis and the …