An investigation of the effect of sorafenib on tumour growth and recurrence after liver cancer resection in nude mice independent of phosphorylated extracellular …
Z Wang, J Hu, SJ Qiu, XW Huang, Z Dai… - Expert opinion on …, 2011 - Taylor & Francis
Objective: The goal of this study is to investigate the effects of sorafenib on tumor growth,
recurrence and metastasis after curative resection of liver cancer. Research methods …
recurrence and metastasis after curative resection of liver cancer. Research methods …
[PDF][PDF] Effect of sorafenib on murine liver regeneration
C Hora, P Romanque, JFF Dufour - Hepatology, 2011 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a common cause of cancer‐related death. Sorafenib
prolongs survival of patients with advanced disease and is approved for the systemic …
prolongs survival of patients with advanced disease and is approved for the systemic …
Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor
NE El-Ashmawy, EG Khedr, HA El-Bahrawy… - Clinical and …, 2017 - Springer
Although sorafenib was approved as antiangiogenic agent in case of hepatocellular
carcinoma (HCC), the pathways mediating its antitumorigenic effects were not fully …
carcinoma (HCC), the pathways mediating its antitumorigenic effects were not fully …
Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma
H Huynh, VC Ngo, HN Koong, D Poon… - Journal of cellular …, 2009 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide. Vascular
endothelial growth factor, platelet derived growth factor and the Raf/mitogen‐activated …
endothelial growth factor, platelet derived growth factor and the Raf/mitogen‐activated …
[PDF][PDF] Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model
Surgical resection is the first‐line treatment for hepatocellular carcinoma (HCC) patients with
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
well‐preserved liver function. Nevertheless, the rate of postoperative recurrence at 5 years is …
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie… - Cancer research, 2006 - AACR
Angiogenesis and signaling through the RAF/mitogen-activated protein/extracellular signal-
regulated kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …
regulated kinase (ERK) kinase (MEK)/ERK cascade have been reported to play important …
Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI‐Foxn1nu mice
C Eicher, A Dewerth, B Kirchner… - Liver …, 2012 - Wiley Online Library
Background Multidrug resistance is a major reason for poor treatment results in advanced
hepatoblastoma (HB). Several alternative treatment options are currently under investigation …
hepatoblastoma (HB). Several alternative treatment options are currently under investigation …
Quantitative examination of the inhibitory activation of molecular targeting agents in hepatocellular carcinoma patient‐derived cell invasion via a novel in vivo tumor …
H Sun, F Feng, H Xie, X Li, Q Jiang… - Animal Models and …, 2019 - Wiley Online Library
Background The outcomes for patients with advanced hepatocellular carcinoma (HCC)
receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib …
receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib …
Sorafenib prolongs liver regeneration after hepatic resection in rats
A Mollbrink, M Augsten, R Hultcrantz… - journal of surgical …, 2013 - Elsevier
Background The multikinase inhibitor sorafenib inhibits angiogenesis and tumor cell
proliferation. Sorafenib targets signaling pathways involved in liver regeneration. Previous …
proliferation. Sorafenib targets signaling pathways involved in liver regeneration. Previous …
Sorafenib suppresses the cell cycle and induces the apoptosis of hepatocellular carcinoma cell lines in serum-free media
M Tomizawa, F Shinozaki… - Experimental and …, 2010 - spandidos-publications.com
To suppress the invasion of hepatocellular carcinoma (HCC) cells into surrounding
connective tissues during metastasis, we investigated the usefulness of sorafenib. In order to …
connective tissues during metastasis, we investigated the usefulness of sorafenib. In order to …