Background The regulatory mechanisms involved in mitochondrial quality control (MQC)
dysfunction during septic cardiomyopathy (SCM) remain incompletely characterized …

Rationale: Ischemic heart disease remains a primary threat to human health, while its
precise etiopathogenesis is still unclear. TBC domain family member 15 (TBC1D15) is a …

Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Abstract Dual specificity phosphatase 1 (DUSP1) and valosin-containing protein (VCP) have
both been reported to regulate mitochondrial homeostasis. However, their impact on …

Current evidence indicates that coronary microcirculation is a key target for protecting
against cardiac ischemia–reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) …

Mitochondrial fission and selective mitochondrial autophagy (mitophagy) form an essential
axis of mitochondrial quality control that plays a critical role in the development of cardiac …

Background Sepsis-induced myocardial dysfunction is associated with worse clinical
outcomes and high mortality, but no effective therapeutic intervention has been explored …

Mitochondrial dysfunction is a salient feature of myocardial ischemia/reperfusion injury
(MIRI), while the potential mechanism of mitochondrial dynamics disorder remains unclear …

Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

Ischemic cardiomyopathy (ICM) is a special type of coronary heart disease or an advanced
stage of the disease, which is related to the pathological mechanism of primary dilated …