The objective of the present study was to examine the role of the angiotensin II type 1
receptor (AT1-R) in the diabetes-aggravated oxidative stress and brain injury observed in a …

The effects of an angiotensin II type 1 (AT1) receptor blocker (ARB) on ischemic brain
damage induced by middle cerebral artery (MCA) occlusion were compared with those of an …

Hyperglycemia during diabetes is one of the causes of encephalopathy. However, diabetes
causes chronic inflammatory complications and among them is peripheral neuropathy …

Background—The role of angiotensin II receptor subtypes was investigated in focal brain
ischemia induced by middle cerebral artery (MCA) occlusion. Methods and Results—In …

One of common pathophysiological states associated with central nervous system is chronic
cerebral hypoperfusion (CH) that frequently occurs in conditions such as vascular dementia …

Both chronic hyperglycemia and ischemia/reperfusion (IR) cause an imbalance in the
oxidative state of tissues. Normoglycemic and streptozotocin (STZ)-diabetic rats were …

The precise mechanisms of vascular diseases in patients with diabetic hypertensive are not
clearly understood. There are evidences of alteration in permeability of blood–brain barrier …

Background and Purpose—We examined the possibility that activation of the human brain
renin–angiotensin system is involved in enhancement of ischemic brain damage using …

To investigate the role of brain angiotensin II (ANG II) in the pathogenesis of injury following
ischemic stroke, mice overexpressing renin and angiotensinogen (R+ A+) and their wild …

Background and Purpose—Stroke and heart disease are the most serious complications of
diabetes accounting for> 65% of mortality among diabetics. Although intensive insulin …