Cerebral ischemia in diabetics results in severe brain damage. Different animal models of
cerebral ischemia have been used to study the aggravation of ischemic brain damage in the …

We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor
(AT2R) agonist is neuroprotective against a subsequent stroke independent of any changes …

Recent investigations have postulated a link between oxidative stress and endoplasmic
reticulum (ER) dysfunction in cerebral ischaemic/reperfusion (I/R) injury. Diabetes is …

Objectives The contribution of the AT 2 and AT 4 angiotensin receptors to the protective role
of the AT 1 receptor blocker candesartan in acute ischemic stroke was investigated. Methods …

Ischemic stroke provokes an inflammatory response concurrent with both sympathetic
nervous system activation and hyperglycemia. Currently, their crosstalk and consequences …

Vascular dysfunction is important in the pathogenesis of peripheral complications of
diabetes. However, the effects of diabetes on cerebral blood flow and the role of vascular …

In the present study, we investigate whether a long-term blockade of brain AT1 receptors in
male Wistar rats before and after ischemic injury exerts neuroprotective effects and …

Inhibition of angiotensin II AT1 receptors protects against stroke, reducing the cerebral blood
flow decrease in the periphery of the ischemic lesion. To clarify the mechanism …

Several lines of clinical and experimental evidence suggest an important role of the
reninangiotensin system in ischemic brain injury although the cellular regulation of the …

Background and Purpose—Angiotensin II, through stimulation of AT1 receptors, not only
controls blood pressure but also modulates cerebrovascular flow. We sought to determine …