Addiction is a chronically relapsing neuropsychiatric disease that occurs in some, but not all,
individuals who use substances of abuse. Relatively little is known about the mechanisms …

Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

Cigarette smoking and alcohol use are among the most prevalent substances used
worldwide and account for a substantial proportion of preventable morbidity and mortality …

Genetic factors are implicated in the heritability of drug abuse. However, even with advances
in current technology no specific genes have been identified that are critical for the …

Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …

BACKGROUND: Addictive disorders are heritable, but the search for candidate functional
polymorphisms playing an etiological role in addiction is hindered by complexity of the …

Addictive diseases, including addiction to heroin, prescription opioids, or cocaine, pose
massive personal and public health costs. Addictions are chronic relapsing diseases of the …