Biological substrates of addiction
This review is an introduction to addiction, the reward circuitry, and laboratory addiction
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking …
models. Addiction is a chronic disease hallmarked by a state of compulsive drug seeking …
Genetic imaging consortium for addiction medicine: from neuroimaging to genes
Since the sample size of a typical neuroimaging study lacks sufficient statistical power to
explore unknown genomic associations with brain phenotypes, several international genetic …
explore unknown genomic associations with brain phenotypes, several international genetic …
Genetic disposition to addictive disorders—current knowledge and future perspectives
P Mayer, V Höllt - Current Opinion in Pharmacology, 2005 - Elsevier
It is well established that addictive disorders have a strong genetic background. Multiple,
and in part interacting, genes are likely to be responsible for the disease phenotype, making …
and in part interacting, genes are likely to be responsible for the disease phenotype, making …
[HTML][HTML] Genome-wide association study of copy number variations (CNVs) with opioid dependence
Single-nucleotide polymorphisms that have been associated with opioid dependence (OD)
altogether account for only a small proportion of the known heritability. Most of the genetic …
altogether account for only a small proportion of the known heritability. Most of the genetic …
Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders
B Porjesz, M Rangaswamy - The Scientific World Journal, 2007 - Wiley Online Library
Biological endophenotypes are more proximal to gene function than psychiatric diagnosis,
providing a powerful strategy in searching for genes in psychiatric disorders. These …
providing a powerful strategy in searching for genes in psychiatric disorders. These …
Genetics of alcohol dependence
M Kimura, S Higuchi - Psychiatry and clinical neurosciences, 2011 - Wiley Online Library
Twin, family, and adoption studies have consistently shown that genetic factors play an
important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to …
important role in the pathogenesis of alcohol dependence. Numerous studies have aimed to …
Addiction and its brain science
R Spanagel, M Heilig - Addiction, 2005 - Wiley Online Library
Aims To illustrate how modern neurobiological approaches will help to identify the
neurocircuits and genes involved in addictive behavior. Background The current disorder …
neurocircuits and genes involved in addictive behavior. Background The current disorder …
[HTML][HTML] Convergent functional genomics in addiction research-a translational approach to study candidate genes and gene networks
R Spanagel - In silico pharmacology, 2013 - Springer
Convergent functional genomics (CFG) is a translational methodology that integrates in a
Bayesian fashion multiple lines of evidence from studies in human and animal models to get …
Bayesian fashion multiple lines of evidence from studies in human and animal models to get …
[HTML][HTML] Epigenetic modulation of brain gene networks for cocaine and alcohol abuse
Cocaine and alcohol are two substances of abuse that prominently affect the central nervous
system (CNS). Repeated exposure to cocaine and alcohol leads to longstanding changes in …
system (CNS). Repeated exposure to cocaine and alcohol leads to longstanding changes in …
[HTML][HTML] Genome wide association for addiction: replicated results and comparisons of two analytic approaches
Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …