Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisited
MM Torregrossa, JJ Quinn… - Biological …, 2008 - biologicalpsychiatryjournal.com
Humans suffering damage to the orbitofrontal cortex (OFC) are often described as impulsive.
The most famous example is Phineas Gage, a railway worker who in 1848 suffered extreme …
The most famous example is Phineas Gage, a railway worker who in 1848 suffered extreme …
The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches
Impulsivity is a multidimensional construct with implications for understanding the etiology
and treatment of multiple forms of psychopathology. As a multidimensional construct …
and treatment of multiple forms of psychopathology. As a multidimensional construct …
Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation
N Broos, L Diergaarde, ANM Schoffelmeer… - …, 2012 - nature.com
Despite the strong association between impulsivity and addiction in humans, it is still a
matter of debate whether impulsive choice predisposes to, or results from, drug …
matter of debate whether impulsive choice predisposes to, or results from, drug …
Loss of willpower: Abnormal neural mechanisms of impulse control and decision making in addiction
Addiction is a condition in which the person becomes unable to choose according to
longterm outcomes when it comes to drugs. We will argue that this is the product of an …
longterm outcomes when it comes to drugs. We will argue that this is the product of an …
Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit
Based on brain imaging findings, we present a model according to which addiction emerges
as an imbalance in the information processing and integration among various brain circuits …
as an imbalance in the information processing and integration among various brain circuits …
The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level
CA Winstanley - Annals of the New York Academy of Sciences, 2007 - Wiley Online Library
The association between impulsivity and addiction is currently a topic of intense research
interest. Investigations into the neurobiological basis of aspects of impulse control have …
interest. Investigations into the neurobiological basis of aspects of impulse control have …
Impulsivity derived from the dark side: Neurocircuits that contribute to negative urgency
EP Zorrilla, GF Koob - Frontiers in behavioral neuroscience, 2019 - frontiersin.org
Negative urgency is a unique dimension of impulsivity that involves acting rashly when in
extreme distress and impairments in inhibitory control. It has been hypothesized to derive …
extreme distress and impairments in inhibitory control. It has been hypothesized to derive …
The role of impulsive behavior in drug abuse
JL Perry, ME Carroll - Psychopharmacology, 2008 - Springer
Background Impulsivity is a multifaceted construct that has recently been recognized as a
factor contributing to enhanced vulnerability to drug abuse. Objectives In the present review …
factor contributing to enhanced vulnerability to drug abuse. Objectives In the present review …
Recent insights into the neurobiology of impulsivity
MR Mitchell, MN Potenza - Current addiction reports, 2014 - Springer
Impulsivity is associated with various psychopathologies, and elevated impulsivity is
typically disadvantageous. This manuscript reviews recent investigations into the …
typically disadvantageous. This manuscript reviews recent investigations into the …
Fractionating impulsivity: neuropsychiatric implications
JW Dalley, TW Robbins - Nature Reviews Neuroscience, 2017 - nature.com
The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …
many settings. However, when persistently expressed, impulsive decisions and actions are …