Impulsivity, compulsivity, and habit: the role of orbitofrontal cortex revisited

MM Torregrossa, JJ Quinn… - Biological …, 2008 - biologicalpsychiatryjournal.com
Humans suffering damage to the orbitofrontal cortex (OFC) are often described as impulsive.
The most famous example is Phineas Gage, a railway worker who in 1848 suffered extreme …

The endophenotype of impulsivity: reaching consilience through behavioral, genetic, and neuroimaging approaches

E Congdon, T Canli - Behavioral and cognitive …, 2005 - journals.sagepub.com
Impulsivity is a multidimensional construct with implications for understanding the etiology
and treatment of multiple forms of psychopathology. As a multidimensional construct …

Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation

N Broos, L Diergaarde, ANM Schoffelmeer… - …, 2012 - nature.com
Despite the strong association between impulsivity and addiction in humans, it is still a
matter of debate whether impulsive choice predisposes to, or results from, drug …

Loss of willpower: Abnormal neural mechanisms of impulse control and decision making in addiction

A Bechara, X Noel, EA Crone - Handbook of implicit cognition …, 2006 - books.google.com
Addiction is a condition in which the person becomes unable to choose according to
longterm outcomes when it comes to drugs. We will argue that this is the product of an …

Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain's control circuit

ND Volkow, GJ Wang, JS Fowler, D Tomasi… - …, 2010 - Wiley Online Library
Based on brain imaging findings, we present a model according to which addiction emerges
as an imbalance in the information processing and integration among various brain circuits …

The orbitofrontal cortex, impulsivity, and addiction: probing orbitofrontal dysfunction at the neural, neurochemical, and molecular level

CA Winstanley - Annals of the New York Academy of Sciences, 2007 - Wiley Online Library
The association between impulsivity and addiction is currently a topic of intense research
interest. Investigations into the neurobiological basis of aspects of impulse control have …

Impulsivity derived from the dark side: Neurocircuits that contribute to negative urgency

EP Zorrilla, GF Koob - Frontiers in behavioral neuroscience, 2019 - frontiersin.org
Negative urgency is a unique dimension of impulsivity that involves acting rashly when in
extreme distress and impairments in inhibitory control. It has been hypothesized to derive …

The role of impulsive behavior in drug abuse

JL Perry, ME Carroll - Psychopharmacology, 2008 - Springer
Background Impulsivity is a multifaceted construct that has recently been recognized as a
factor contributing to enhanced vulnerability to drug abuse. Objectives In the present review …

Recent insights into the neurobiology of impulsivity

MR Mitchell, MN Potenza - Current addiction reports, 2014 - Springer
Impulsivity is associated with various psychopathologies, and elevated impulsivity is
typically disadvantageous. This manuscript reviews recent investigations into the …

Fractionating impulsivity: neuropsychiatric implications

JW Dalley, TW Robbins - Nature Reviews Neuroscience, 2017 - nature.com
The ability to make decisions and act quickly without hesitation can be advantageous in
many settings. However, when persistently expressed, impulsive decisions and actions are …