Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning

J Wang, C Liu, L Yang, H Chen, M Zheng, Y Wan… - Scientific Reports, 2023 - nature.com
The patterns of communication among different chondrocyte subtypes in human cartilage
degeneration and regeneration help us understand the microenvironment of osteoarthritis …

Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis

X Kang, K Zhang, Y Wang, Y Zhao, Y Lu - Frontiers in cell and …, 2023 - frontiersin.org
Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative
articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence …

Single-cell RNA sequencing reveals different chondrocyte states in femoral cartilage between osteoarthritis and healthy individuals

Z Sun, M Yan, J Wang, H Zhang, X Ji, Y Xiao… - Frontiers in …, 2024 - frontiersin.org
Background Cartilage injury is the main pathological manifestation of osteoarthritis (OA).
Healthy chondrocyte is a prerequisite for cartilage regeneration and repair. Differences …

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

Q Ji, Y Zheng, G Zhang, Y Hu, X Fan, Y Hou… - Annals of the …, 2019 - ard.bmj.com
Objectives Understanding the molecular mechanisms underlying human cartilage
degeneration and regeneration is helpful for improving therapeutic strategies for treating …

The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes

EA Lewallen, CA Bonin, X Li, J Smith, M Karperien… - Gene, 2016 - Elsevier
Osteoarthritis (OA) is a disabling degenerative joint disease that prompts pain and has
limited treatment options. To permit early diagnosis and treatment of OA, a high resolution …

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis

C Huang, B Zeng, B Zhou, G Chen, Q Zhang, W Hou… - Genes & …, 2024 - Elsevier
Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of
chondrocytes in human articular cartilage is still not well defined, which hinders our …

Identification of cellular heterogeneity and immunogenicity of chondrocytes via single-cell RNA sequencing technique in human osteoarthritis

X Hu, Z Li, M Ji, Y Lin, Y Chen, J Lu - Frontiers in Pharmacology, 2022 - frontiersin.org
Background: Osteoarthritis (OA) has placed a heavy burden to the economy and
humanistics. To explore the biological functions and markers of chondrocytes contributes …

[HTML][HTML] Single-cell transcriptomics reveals variable trajectories of CSPCs in the progression of osteoarthritis

L Qi, J Wang, X Chen, Y Ding, B Ling, W Wang, J Xu… - Heliyon, 2022 - cell.com
Osteoarthritis (OA) is characterised by cartilage destruction; however, there are no specific
drugs available for its treatment. Cartilage-derived stem/progenitor cells (CSPCs) are …

Single-cell profiles of age-related osteoarthritis uncover underlying heterogeneity associated with disease progression

W Liu, Y Chen, G Zeng, S Yang, T Yang… - Frontiers in Molecular …, 2022 - frontiersin.org
Objective: Osteoarthritis (OA) is the most common chronic degenerative joint disease, which
represents the leading cause of age-related disability. Here, this study aimed to depict the …

Single-cell RNA sequencing reveals distinct chondrocyte states in femoral cartilage under weight-bearing load in Rheumatoid arthritis

M Yan, Z Sun, J Wang, H Zhao, T Yu, Y Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction Rheumatoid arthritis (RA) is a common autoimmune joint disease, the
pathogenesis of which is still unclear. Cartilage damage is one of the main manifestations of …