Minocycline is an antibiotic with anti-inflammatory and antiapoptotic properties that prolongs
survival in a transgenic Huntington disease (HD) mouse model. In a double-blind …

Huntington's Disease (HD) is an inherited neurological disorder causing movement
impairment, personality changes, dementia, and premature death, for which there is …

Despite advances in understanding the pathogenesis of Huntington's disease (HD), there is
no effective treatment. In the HD transgenic mouse, expression of a dominant-negative …

Smith and colleagues evaluate minocycline and doxycycline in the R6/2 mouse model of
Huntington's disease (HD) and conclude that these drugs are not effective. 1 The findings …

We present the case of a patient with advanced Huntington's disease treated with
minocycline. Minocycline (but not tetracycline which does not cross the blood–brain barrier) …

According to the recent controversy regarding the effects of minocycline in the R6/2
transgenic model of Huntington's disease (HD), this tetracycline has been re-evaluated in …

Minocycline has been shown to be neuroprotective in various models of neurodegenerative
diseases. However, its potential in Huntington's disease (HD) models characterized by …

Abstract Huntington's disease (HD), a relentlessly progressive neurodegenerative disorder,
is characterized by a clinical triad of psychiatric, cognitive and motor disturbances. The …

The capacity of minocycline to alleviate disease for several neurological disorders in
animals is increasingly being recognised. Indeed, that one drug alone can attenuate the …

Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and
has been shown to delay disease progression in the mouse model R6/2 of Huntington's …