The design of a combination drug protocol must take into account the toxicology and
pharmacology of the individual agents and the extent to which they interact with each other …

UNTIL now, attempts to identify in tumour cells a selective biochemical differ-ence which
might be susceptible to selective chemical attack have not been successful. However …

Although there has been steady progress with respect to the proportion of patients with
certain types of neoplasms that can be cured with chemotherapy, the fact remains that the …

At the present time the most useful and effective agents for the systemic treatment of cancer
are the antineoplastic drugs generally characterized as" cytotoxic" and the steroid …

Despite its successes cancer chemotherapy fails to cure the great majority of patients treated
(2). This failure is due to the overgrowth of resistant cells. The final common pathway of all …

Were it not for the resistance of human tumors to antineoplastic agents, disseminated cancer
would not be a clinical problem, and in fact surgery and radiotherapy would be passé. All too …

Progress in the treatment of cancer with drugs has radically altered the clinical approach to
patients with malignancy. Not only have new drugs produced promising results in hitherto …

Modern cancer chemotherapy began with alkylating agents. They have been shown to have
broad-spectrum therapeutic activity against tumors in laboratory animals [10, 23, 28, 35] and …

Resistance to drugs active in the treatment of cancer is one of the most frustrating of all
cancer treatment problems. The magnitude of the problem and its impact on cancer mortality …

Human cancers are either refractory to chemotherapy, or acquire resistance to it. Although
acquired resistance to chemotherapy is generally ascribed to the drug itself, it may be linked …