Conspectus Catalysis is a fundamental chemical concept, and many kinds of catalysts have
considerable practical value. Developing entirely new catalysts is an exciting challenge …

This study focuses on the development of DNA catalysts (deoxyribozymes) that modify side
chains of peptide substrates, with the long-term goal of achieving DNA-catalyzed covalent …

The discovery of naturally occurring catalytic RNA (RNA enzymes, or ribozymes) in the
1980s immediately revised the view of RNA as a passive messenger that solely carries …

DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro
selection. However, for certain reactions this identification has not been achieved. One …

One of the chemist's key motivations is to explore the forefront of catalysis. In this Account,
we describe our laboratory's efforts at one such forefront: the use of DNA as a catalyst …

Deoxyribozymes are DNA molecules with catalytic activity. For historical and practical
reasons, essentially all reported deoxyribozymes catalyze reactions of nucleic acid …

We previously reported that DNA catalysts (deoxyribozymes) can hydrolyze DNA
phosphodiester linkages, but DNA-catalyzed amide bond hydrolysis has been elusive. Here …

Deoxyribozymes (DNA catalysts) have been reported for cleavage of RNA phosphodiester
linkages, but cleaving peptide or DNA phosphodiester linkages is much more challenging …

Deoxyribozymes are particular DNA sequences that have catalytic ability, analogous to
protein enzymes as functional amino acid sequences.[1, 2] The discovery of natural RNA …

We report DNA catalysts (deoxyribozymes) that join tyrosine‐containing peptides to RNA
and DNA in one step and without requiring protecting groups on either the peptide or the …