Microglial heterogeneity in chronic pain
G Sideris-Lampretsas, M Malcangio - Brain, Behavior, and Immunity, 2021 - Elsevier
In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …
as sex affect microglia functions in health. We highlight that recent advances in …
[HTML][HTML] Repopulated spinal cord microglia exhibit a unique transcriptome and contribute to pain resolution
Microglia are implicated as primarily detrimental in pain models; however, they exist across
a continuum of states that contribute to homeostasis or pathology depending on timing and …
a continuum of states that contribute to homeostasis or pathology depending on timing and …
Macrophages and microglia in inflammation and neuroinflammation underlying different pain states
Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory
mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types …
mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types …
Controlled activation of cortical astrocytes modulates neuropathic pain-like behaviour
I Takeda, K Yoshihara, DL Cheung, T Kobayashi… - Nature …, 2022 - nature.com
Chronic pain is a major public health problem that currently lacks effective treatment options.
Here, a method that can modulate chronic pain-like behaviour induced by nerve injury in …
Here, a method that can modulate chronic pain-like behaviour induced by nerve injury in …
The role of microglial purinergic receptors in pain signaling
Pain is an essential modality of sensation in the body. Purinergic signaling plays an
important role in nociceptive pain transmission, under both physiological and …
important role in nociceptive pain transmission, under both physiological and …
Microglial regulation of neuropathic pain
Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …
Epigenetic mechanisms of neural plasticity in chronic neuropathic pain
Neuropathic pain is a challenging clinical problem and remains difficult to treat. Altered gene
expression in peripheral sensory nerves and neurons due to nerve injury is well …
expression in peripheral sensory nerves and neurons due to nerve injury is well …
Role of microglia and P2X4 receptors in chronic pain
K Kohno, M Tsuda - Pain Reports, 2021 - journals.lww.com
Pain plays an indispensable role as an alarm system to protect us from dangers or injuries.
However, neuropathic pain, a debilitating pain condition caused by damage to the nervous …
However, neuropathic pain, a debilitating pain condition caused by damage to the nervous …
Microglia and chronic pain
M Malcangio - Pain, 2016 - journals.lww.com
Supported by the Wellcome Trust (WT081553AIA and Travel fellowship to Anna Clark,
WT093173/Z/10/Z); MRC grant MR/M023893/1, ARUK grants MP/18277 and 20020 …
WT093173/Z/10/Z); MRC grant MR/M023893/1, ARUK grants MP/18277 and 20020 …
The role of mitogen activated protein kinase signaling in microglia and neurons in the initiation and maintenance of chronic pain
ED Crown - Experimental neurology, 2012 - Elsevier
Effective treatments for patients suffering from chronic pain remain an area of intense focus
within the pharmaceutical industry, as the development of novel therapies would help to …
within the pharmaceutical industry, as the development of novel therapies would help to …