The dominant view in the field of pain is that peripheral neuropathic pain is driven by
microglia in the somatosensory processing region of the spinal dorsal horn. Here, to the …

The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of
the rapidly developing field of pain research. As populations age, the number of people in …

The process of pain perception begins in the periphery by activation of nociceptors. From
here nociceptive signals are conveyed via the dorsal horn of the spinal cord to multiple brain …

It is now well established that glial cells not only provide mechanical and trophic support to
neurons but can directly contribute to neurotransmission, for example, by release and …

Over the last decade, a series of studies has demonstrated that glia in the central nervous
system play roles in many aspects of neuronal functioning including pain processing …

Synaptic plasticity is thought to be initiated by neurons only, with the prevailing view
assigning glial cells mere specify supportive functions for synaptic transmission and …

The high prevalence of pain and the at times low efficacy of current treatments represent a
significant challenge to healthcare systems worldwide. Effective treatment strategies require …

Neuropathic pain after peripheral nerve damage is a lasting condition that generally persists
even when the cause of damage disappears. The immune system is integral to the …

Pain is classically viewed as being mediated solely by neurons, as are other sensory
phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain …

Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …