Acidic postconditioning by transient CO2 inhalation applied within minutes after reperfusion
has neuroprotective effects in the acute phase of stroke. However, the effects of delayed …

Acidosis is one of the key components in cerebral ischemic postconditioning that has
emerged recently as an endogenous strategy for neuroprotection. We set out to test whether …

T-cell death-associated gene 8 (TDAG8), a G-protein-coupled receptor sensing
physiological or weak acids, regulates inflammatory responses. However, its role in …

Stroke is one of the leading causes of mortality and disability worldwide, with limited
therapeutic approaches. As an endogenous strategy for neuroprotection, postconditioning …

Aims Few treatments are available in the subacute phase of traumatic brain injury (TBI)
except rehabilitation training. We previously reported that transient CO2 inhalation applied …

Ischemic postconditioning provides robust neuroprotection, therefore, determining the
molecular events may provide promising targets for stroke treatment. Here, we showed that …

Extracellular acidification in the brain has been observed in ischemia; however, the
physiological and pathophysiological implications of the pH reduction remain largely …

Narrow therapeutic window limits treatments with thrombolysis and neuroprotection for most
stroke patients. Widening therapeutic window remains a critical challenge. Understanding …

Aim Cerebral ischemic postconditioning has emerged recently as a kind of endogenous
strategy for neuroprotection. We set out to test whether hypoxia or glucose deprivation (GD) …

Following cerebral ischemia/reperfusion (I/R) injury, a series of pathophysiological
processes are stimulated in both the central nervous system (CNS) and the periphery …