In the forebrain, synaptic glycine concentrations are regulated through the glycine
transporter GlyT1. Because glycine is a coagonist of the N-methyl-d-aspartate (NMDA) …

NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu)
targets in the central nervous system and are involved in synaptic plasticity, which is the …

The recent discovery of glycine transporters in both the CNS and the periphery suggests that
the glycine transporter may play a critical role in NMDA receptor function by modulating …

J. Neurochem.(2010) 114, 647–653. Abstract Glycine transporter 1 (GLYT1) and GLYT2 are
the glycine transporters in CNS. While GLYT2 is largely expressed in glycinergic neurons …

Summary The glycine transporter 1 (GlyT1) plays a crucial role in the regulation of both
inhibitory and excitatory neurotransmission by removing glycine from the synaptic cleft …

In the central nervous system, glutamate is essential for a proper synaptic communication in
neuronal networks supporting critical behavioral activities such as learning and memory …

A growing body of evidence suggests that activation of the glutamatergic system, particularly
N-methyl-d-aspartate (NMDA) receptor function, may be a viable approach to the treatment …

Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Current antipsychotic drugs are only partially effective in treating schizophrenia and there is
a clear need to develop better therapies. An alternative approach to develop new …

Schizophrenia is characterized by positive symptoms such as hallucinations, negative
symptoms such as blunted affect, and symptoms of cognitive deficiency such as deficits in …