At least 11 families of distinct phosphodiesterase (PDE) isoenzymes are known to regulate
the function of many cells secondary to altering the intracellular levels of second …

Phosphodiesterases (PDE) are a family of enzymes responsible for the metabolism of the
intracellular second messengers cyclic AMP and cyclic GMP. PDE4 is a cyclic AMP specific …

The concept of “second messengers” operating within cells, transducing the signals
impinging on cell membranes, became well-established from the pioneering work of …

Phosphodiesterase 4 (PDE 4) enzymes are the principal phosphodiesterases responsible
for the hydrolysis of cAMP in pro-inflammatory leukocytes. The functional consequences of …

Publisher Summary This chapter focuses on phosphodiesterase-4 (PDE4) enzyme inhibitors
and their potential therapeutic utility. The chapter presents the in vitro pharmacology of …

Phosphodiesterases (PDEs) are a superfamily of enzymes that catalyze the breakdown of
cAMP and/or cyclic guanosine monophosphate (GMP) to their inactive form. PDE4 is the …

Introduction: PDE inhibitors could be useful in the treatment of asthma because of their
bronchodilator and/or anti-inflammatory activities. Recently, some selective PDE3, PDE4 …

This paper reviews the literature on the modulation of cyclic adenosine 3′ 5′-
monophosphates (cAMP) by inhibition of phosphodiesterase 4 (PDE 4) enzyme. It highlights …

Publisher Summary This chapter describes the various aspects of phosphodiesterase 4
(PDE4) inhibitors. PDE4 is the predominant isozyme present in inflammatory cells and …

Phosphodiesterase enzymes are responsible for the inactivation of cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Phosphodiesterase …