Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies
S Miller, H Liu, K Warfvinge, L Shi, M Dovlatyan, C Xu… - Neuroscience, 2016 - Elsevier
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator
implicated in the pathophysiology of migraine. It binds to the extracellular domains of …
implicated in the pathophysiology of migraine. It binds to the extracellular domains of …
Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion
S Eftekhari, CA Salvatore, A Calamari, SA Kane, J Tajti… - Neuroscience, 2010 - Elsevier
Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP
receptor antagonists have demonstrated clinical efficacy in the treatment of migraine …
receptor antagonists have demonstrated clinical efficacy in the treatment of migraine …
Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat …
Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …
CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?
The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …
Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence …
S Eftekhari, RC Gaspar, R Roberts… - Journal of …, 2016 - Wiley Online Library
Functional imaging studies have revealed that certain brainstem areas are activated during
migraine attacks. The neuropeptide calcitonin gene–related peptide (CGRP) is associated …
migraine attacks. The neuropeptide calcitonin gene–related peptide (CGRP) is associated …
Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion
Z Zhang, CS Winborn, BM de Prado… - Journal of …, 2007 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has
been established as a key player in the pathogenesis of migraine. In this study, we provide …
been established as a key player in the pathogenesis of migraine. In this study, we provide …
Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine
PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …
CGRP receptor antagonism and migraine therapy
L Edvinsson, K Warfvinge - Current Protein and Peptide …, 2013 - ingentaconnect.com
Migraine is the most prevalent of the neurological disorders and can affect the patient
throughout the lifetime. Calcitonin gene-related peptide (CGRP) is a neuropeptide that is …
throughout the lifetime. Calcitonin gene-related peptide (CGRP) is a neuropeptide that is …
CGRP and its receptors
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still
evolving target for migraine. A fundamental consideration for all of the current drugs in …
evolving target for migraine. A fundamental consideration for all of the current drugs in …
CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1
KJ Bohn, B Li, X Huang, BN Mason… - British journal of …, 2017 - Wiley Online Library
Background and Purpose CGRP is a potent vasodilator and nociceptive neuropeptide linked
to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 …
to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 …