Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies

S Miller, H Liu, K Warfvinge, L Shi, M Dovlatyan, C Xu… - Neuroscience, 2016 - Elsevier
Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator
implicated in the pathophysiology of migraine. It binds to the extracellular domains of …

Differential distribution of calcitonin gene-related peptide and its receptor components in the human trigeminal ganglion

S Eftekhari, CA Salvatore, A Calamari, SA Kane, J Tajti… - Neuroscience, 2010 - Elsevier
Calcitonin gene related peptide (CGRP) has a key role in migraine and recently CGRP
receptor antagonists have demonstrated clinical efficacy in the treatment of migraine …

Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat …

JK Lennerz, V Rühle, EP Ceppa… - Journal of …, 2008 - Wiley Online Library
Calcitonin gene‐related peptide (CGRP) is a key mediator in primary headaches including
migraine. Animal models of meningeal nociception demonstrate both peripheral and central …

CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

CS Walker, DL Hay - British Journal of Pharmacology, 2013 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …

Localization of CGRP receptor components and receptor binding sites in rhesus monkey brainstem: A detailed study using in situ hybridization, immunofluorescence …

S Eftekhari, RC Gaspar, R Roberts… - Journal of …, 2016 - Wiley Online Library
Functional imaging studies have revealed that certain brainstem areas are activated during
migraine attacks. The neuropeptide calcitonin gene–related peptide (CGRP) is associated …

Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion

Z Zhang, CS Winborn, BM de Prado… - Journal of …, 2007 - Soc Neuroscience
The neuropeptide calcitonin gene-related peptide (CGRP) from the trigeminal ganglion has
been established as a key player in the pathogenesis of migraine. In this study, we provide …

Inhibition of calcitonin gene‐related peptide function: a promising strategy for treating migraine

PL Durham - Headache: The Journal of Head and Face Pain, 2008 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is implicated in the underlying
pathology of migraine. Serum levels of CGRP, which are elevated during a migraine attack …

CGRP receptor antagonism and migraine therapy

L Edvinsson, K Warfvinge - Current Protein and Peptide …, 2013 - ingentaconnect.com
Migraine is the most prevalent of the neurological disorders and can affect the patient
throughout the lifetime. Calcitonin gene-related peptide (CGRP) is a neuropeptide that is …

CGRP and its receptors

DL Hay, CS Walker - Headache: The Journal of Head and Face …, 2017 - Wiley Online Library
The calcitonin gene‐related peptide (CGRP) neuropeptide system is an important but still
evolving target for migraine. A fundamental consideration for all of the current drugs in …

CGRP receptor activity in mice with global expression of human receptor activity modifying protein 1

KJ Bohn, B Li, X Huang, BN Mason… - British journal of …, 2017 - Wiley Online Library
Background and Purpose CGRP is a potent vasodilator and nociceptive neuropeptide linked
to migraine. CGRP receptors are heterodimers of receptor activity modifying protein 1 …