An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III
secretion system that transfers six Yop effector proteins into host cells. One of these proteins …

Virulence of Yersinia pestis in mammals requires the type III secretion system, which
delivers seven effector proteins into the cytoplasm of host cells to undermine immune …

Numerous microbial pathogens modulate or interfere with cell death pathways in cultured
cells. However, the precise role of host cell death during in vivo infection remains poorly …

Yersinia pestis (Yp)-one of the world's most deadly human pathogens-is the gram-negative
bacterium that causes pneumonic plague. Virulent antibiotic-resistant Yp strains exist and …

The enteropathogenic Yersinia strains are known to downregulate signaling pathways in
macrophages by effectors of the type III secretion system, in which YopJ/YopP plays a …

Yersinia pestis, the etiologic agent of plague, delivers six Yersinia outer proteins (Yops) into
host cells upon direct bacterial contact. One of these, YopM, is necessary for virulence in a …

YopP in Y. enterocolitica and YopJ in Y. pseudotuberculosis, have been shown to exert a
variety of adverse effects on cell signaling leading to suppression of cytokine expression …

Yersinia pestis is the causative agent of plague, a disease that can manifest as either
bubonic or pneumonic plague. An interesting feature of plague is that it is a rapidly …

Publisher Summary Bubonic plague caused by Yersinia pestis ranks as the most severe
bacterial disease known to humanity. In the mouse, this bleak process consists of an initial …