During embryonic life, the development of a proper mass of mature pancreatic tissue is
thought to require the proliferation of precursor cells, followed by their differentiation into …

A comparative analysis of mouse and human pancreatic development may reveal common
mechanisms that control key steps as organ morphogenesis and cell proliferation and …

Cell signals produced during pancreas embryogenesis regulate pancreatic differentiation.
We show that the developing pancreas releases soluble factors responsible for in vitro …

Given the inherent therapeutic potential of the morphogenetic plasticity of adult human islets,
the identification of factors controlling their cellular differentiation is of interest. The …

Type 1 diabetes results from an insufficiency of insulin production as a result of autoimmune
destruction of the insulin-secreting pancreatic beta-cells. It can be treated by transplantation …

The upregulation of a limited number of growth factors in our interferon-γ transgenic model
for regeneration within the pancreas lead us to propose that these factors are important …

Islet transplantation has proven to be a successful strategy to restore normoglycemia in
patients with type 1 diabetes (T1D). However, the dearth of cadaveric islets available for …

Diabetes is characterized by decreased function of insulin‐producing β cells and insufficient
insulin output resulting from an absolute (Type 1) or relative (Type 2) inadequate functional …

The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes
mellitus requires methods to control the development of multipotent cells. We report that …

In the developing embryo, appropriate patterning of the endoderm fated to become
pancreas requires the spatial and temporal coordination of soluble factors secreted by the …