Objective: We aimed to investigate the biological significance of cell cycle regulators in
gastric carcinoma. Methods: Immunohistochemistry and TUNEL staining were performed on …

The cell cycle progression is regulated by interactions of specific cyclin-dependent kinases
at the G1-S and G2-M checkpoints. In addition, the cell cycle dysregulation plays a major …

AimsThe deregulation of cyclin, cyclin-dependent kinases (CDKs) and their inhibitors could
have a crucial role in the development of diverse human cancers. MethodsIn this study, we …

Background Cyclin E is a protein that plays a key role in the G1→ S transition of the normal
cell cycle. The product of retinoblastoma gene (pRb) is the master regulator of entry into the …

Background: The early indicator for the subject predisposed to gastric cancer is abnormal
proliferation of gastric epithelial cells, such as atrophic gastritis (AG), intestinal metaplasia …

AIM: To detect the genetic alteration and abnormal expression of cyclin D1 in gastric
carcinoma and investigate its clinicopathologic significance in advanced gastric carcinoma …

Background. Cell-cycle control is important in carcinogenesis and cancer progression. p27
and cyclin E are cell-cycle regulators, which control the G1-S phase transition. Recently …

Cell cycle regulators cyclin D1 and cyclin E2 function in G1/S transition by activating
downstream cyclin-dependent kinases. Deregulated expression of these cyclins has been …

Background Deregulated expression of cell cycle regulators p27 and p16 is associated with
cancer progression. p27 kip1 and p16 INKa are a cyclin dependent kinase inhibitor whose …

BACKGROUND Cyclin E and p27 play opposing roles in the cell cycle. This study
investigated the protein expression of p27 with cyclin E in the progression and prognosis of …