Abstract FACT (FAcilitates Chromatin Transcription/Transactions) plays a central role in
transcription and replication in eukaryotes by both establishing and overcoming the …

The pob3-Q308K mutation alters the small subunit of the Saccharomyces cerevisiae
histone/nucleosome chaperone Facilitates Chromatin Transactions (FACT), causing defects …

Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and
Pham et al. explore how the histone: DNA contact at the entry/exit site of nucleosomes …

Nucleosome assembly in vivo requires assembly factors, such as histone chaperones, to
bind to histones and mediate their deposition onto DNA. In yeast, the essential histone …

The histone chaperone FACT (FAcilitates Chromatin Transcription) modulates nucleosome
structure during many processes requiring access to chromatinized DNA. Here, we review …

In eukaryotic cells, DNA maintenance requires ordered disassembly and re-assembly of
chromatin templates. These processes are highly regulated and require extrinsic factors …

Changes in chromatin architecture induced by epigenetic mechanisms are essential for
normal cellular processes such as gene expression, DNA repair, and cellular division …

The essential histone chaperone FACT plays a critical role in DNA replication, repair, and
transcription, primarily by binding to histone H2A-H2B dimers and regulating their assembly …

FACT is a histone chaperone that participates in nucleosome removal and reassembly
during transcription and replication. We used electron microscopy to study FACT, FACT …

Human FAcilitates Chromatin Transcription (hFACT) is a conserved histone chaperone that
was originally described as a transcription elongation factor with potential nucleosome …