Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

L Sturla, E Mannino, S Scarfi, S Bruzzone… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abscisic acid (ABA) is a plant hormone also present in animals, where it is involved in the
regulation of innate immune cell function and of glucose disposal, through its receptor …

Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
Abscisic acid (ABA) is a hormone with a very long evolutionary history, dating back to the
earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely the …

[HTML][HTML] LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway

S Spinelli, G Begani, L Guida, M Magnone… - Molecular …, 2021 - Elsevier
Objective Abscisic acid (ABA) is a plant hormone also present and active in animals. In
mammals, ABA regulates blood glucose levels by stimulating insulin-independent glucose …

Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation

M Magnone, L Emionite, L Guida, T Vigliarolo… - Scientific reports, 2020 - nature.com
Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at
nanomolar concentrations, blood glucose homeostasis. Here we investigated the …

The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure

S Spinelli, V Cossu, M Passalacqua… - International Journal of …, 2023 - mdpi.com
The abscisic acid (ABA)/LANC-like protein 1/2 (LANCL1/2) hormone/receptor system
regulates glucose uptake and oxidation, mitochondrial respiration, and proton gradient …

Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle

A Leber, R Hontecillas, N Tubau-Juni… - Scientific Reports, 2020 - nature.com
Abscisic acid is a phytohormone found in fruits and vegetables and is endogenously
produced in mammals. In humans and mice, lanthionine synthetase C-like 2 (LANCL2) has …

[HTML][HTML] Abscisic acid: a novel nutraceutical for glycemic control

E Zocchi, R Hontecillas, A Leber, A Einerhand… - Frontiers in …, 2017 - frontiersin.org
Abscisic acid is naturally present in fruits and vegetables, and it plays an important role in
managing glucose homeostasis in humans. According to the latest US dietary survey, about …

Abscisic acid improves insulin action on glycemia in insulin-deficient mouse models of type 1 diabetes

M Magnone, S Spinelli, G Begani, L Guida, L Sturla… - Metabolites, 2022 - mdpi.com
Abscisic acid (ABA), a plant hormone, has recently been shown to play a role in glycemia
regulation in mammals, by stimulating insulin-independent glucose uptake and metabolism …

Abscisic acid stimulates glucagon-like peptide-1 secretion from L-cells and its oral administration increases plasma glucagon-like peptide-1 levels in rats

S Bruzzone, M Magnone, E Mannino, G Sociali… - PLoS …, 2015 - journals.plos.org
In recent years, Abscisic Acid (ABA) has been demonstrated to be involved in the regulation
of glucose homeostasis in mammals as an endogenous hormone, by stimulating both …

Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2

E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …