The investigation of tissue penetration and distribution of antibiotics is of great importance,
since infections occur mostly in the tissues. The aim of this study was to investigate the …

The tissue penetration and distribution of antibiotics is of great importance, since most of the
infections occur in the tissue. At the infection site, the free, unbound fraction of the antibiotic …

Objectives The pharmacokinetic profile of antibiotics at the site of anti‐infective action is one
of the most important determinants of drug response, since it correlates with antimicrobial …

The pharmacokinetics of tazobactam (500 mg) administered intravenously alone were
compared with the pharmacokinetics of tazobactam coadministered with piperacillin (4 g) …

The pharmacokinetic properties of piperacillin/tazobactam are summarized. The data on
piperacillin show that the behaviour of this well established agent is the same when given in …

Study Objective. To determine the appropriate compartmental and noncompartmental
pharmacokinetic parameters for intravenous piperacillin and tazobactam. Design …

Piperacillin/tazobactam is a new drug consisting of a highly active penicillin and a beta-
lactamase inhibitor. Pharmacokinetic variables of both components after they have been …

We investigated the pharmacokinetics of piperacillin and tazobactam in the extracellular
space fluid of inflamed soft tissues of six patients with diabetic foot infection using in vivo …

The calculation of pharmacokinetic/pharmacodynamic surrogates from concentrations in
serum has been shown to yield important information for the evaluation of antibiotic …

The pharmacokinetics of tazobactam and piperacillin in plasma and different tissues after a
30-min intravenous infusion of 4 g of piperacillin and 0.5 g of tazobactam were investigated …