Factors affecting trough plasma dabigatran concentrations in patients with atrial fibrillation and chronic kidney disease

A Skripka, D Sychev, P Bochkov, R Shevchenko… - High Blood Pressure & …, 2020 - Springer
Introduction Dabigatran is effective and widely used to prevent ischemic stroke and systemic
embolism (SE) in patients with atrial fibrillation (AF). Chronic kidney disease (CKD) also has …

Factors influencing trough and 90-minute plasma dabigatran etexilate concentrations among patients with non-valvular atrial fibrillation

H Tomita, T Araki, T Kadokami, S Yamada… - Thrombosis …, 2016 - Elsevier
Introduction Dabigatran etexilate, a direct oral anti-coagulation agent, is used in the
prevention of thromboembolism in patients with non-valvular atrial fibrillation (NVAF) …

Real‐world variability in dabigatran levels in patients with atrial fibrillation

NC Chan, M Coppens, J Hirsh… - … of Thrombosis and …, 2015 - Wiley Online Library
Background In clinical practice, physicians are given the choice of selecting one of two
dabigatran doses based on patient characteristics, with the lower dose typically used in …

[HTML][HTML] Factors affecting serum concentration of dabigatran in Asian patients with non-valvular atrial fibrillation

SY Lin, SC Tang, CH Kuo, LK Tsai, SJ Yeh… - Journal of the Formosan …, 2019 - Elsevier
Background/purpose Dabigatran is effective in preventing ischemic stroke and systemic
embolism in patients with atrial fibrillation. Although the therapeutic window for dabigatran is …

A systematic review and meta‐analysis of dabigatran peak and trough concentration in adults

JW Ng, NA Mohd Tahir, PKL Chin… - British Journal of …, 2022 - Wiley Online Library
Dabigatran etexilate is an oral direct thrombin inhibitor used in preventing thromboembolism
in patients with atrial fibrillation and several other conditions. Routine dabigatran …

Relation between dabigatran concentration, as assessed using the direct thrombin inhibitor assay, and activated clotting time/activated partial thromboplastin time in …

K Okubo, T Kuwahara, K Takagi, M Takigawa… - The American Journal of …, 2015 - Elsevier
Dabigatran is a direct thrombin inhibitor that has been approved for preventing stroke in
patients with atrial fibrillation. In this study, we aimed to assess the associations between the …

On the monitoring of dabigatran treatment in “real life” patients with atrial fibrillation

M Skeppholm, P Hjemdahl, JP Antovic, J Muhrbeck… - Thrombosis research, 2014 - Elsevier
Introduction The oral direct thrombin inhibitor dabigatran is increasingly used to prevent
thromboembolic stroke in patients with atrial fibrillation (AF). Routine laboratory monitoring is …

Dabigatran concentration: variability and potential bleeding prediction in “real–life” patients with atrial fibrillation

P Šinigoj, RE Malmström, N Vene… - Basic & clinical …, 2015 - Wiley Online Library
Routine laboratory monitoring is currently not recommended in patients receiving dabigatran
despite its considerable variation in plasma concentration. However, in certain clinical …

[HTML][HTML] Safety of low-dose dabigatran in patients with atrial fibrillation and mild renal insufficiency

H Fukaya, S Niwano, J Oikawa, R Nishinarita… - Journal of …, 2017 - Elsevier
Background Dabigatran etexilate (DE), an effective direct oral anticoagulant for patients with
atrial fibrillation (AF), should be carefully used in patients with renal insufficiency. Data on …

Real-world variability in dabigatran levels in patients with atrial fibrillation: comment

J Douxfils, B Chatelain, JM Dogné… - Journal of Thrombosis and …, 2015 - jthjournal.org
We read with interest the recent prospective observational study by Chan et al.[1] The
authors aimed to investigate the interpatient and intrapatient variabilities in dabigatran …