In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the
causative agent of plague, a signature-tagged mutagenesis strategy was used and …

Three great plague pandemics caused by the gram-negative bacterium Yersinia pestis have
killed nearly 200 million people and it has been linked to biowarfare in the past. Plague is …

The etiologic agent of plague, Yersinia pestis, is a globally distributed pathogen which
poses both a natural and adversarial threat. Due largely to the rapid course and high …

An important virulence strategy evolved by bacterial pathogens to overcome host defenses
is the modulation of host cell death. Previous observations have indicated that Yersinia …

Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is
no ideal plague vaccine available for human use, but a number of licensed killed whole-cell …

The median lethal dose (MLD) of a pathogenic strain of Yersinia pestis was established by
three routes of administration in three strains of mouse. There was no significant difference …

Live attenuated and killed whole cell vaccines against disease caused by Yersinia pestis
have been available since the early part of the last century. Although these vaccines indicate …

Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y.
pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll …

Yersinia pestis, the agent of plague, is among the deadliest bacterial pathogens affecting
humans, and is a potential biological weapon. Because antibiotic resistant strains of …

V antigen of Yersinia pestis is a multifunctional protein that has been implicated as a
protective antigen, a virulence factor, and a regulatory protein. A series of V-antigen …