Three decades of research on O-GlcNAcylation–a major nutrient sensor that regulates signaling, transcription and cellular metabolism
GW Hart - Frontiers in endocrinology, 2014 - frontiersin.org
Even though the dynamic modification of polypeptides by the monosaccharide, O-linked N-
acetylglucosamine (O-GlcNAcylation) was discovered over 30 years ago, its physiological …
acetylglucosamine (O-GlcNAcylation) was discovered over 30 years ago, its physiological …
Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification
N-Acetylglucosamine O-linked to serines and threonines of cytosolic and nuclear proteins (O-
GlcNAc) is an abundant reversible post-translational modification found in all higher …
GlcNAc) is an abundant reversible post-translational modification found in all higher …
O-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains
Nucleocytoplasmic glycosylation of proteins with O-linked N-acetylglucosamine residues (O-
GlcNAc) is recognized as a conserved post-translational modification found in all …
GlcNAc) is recognized as a conserved post-translational modification found in all …
O-GlcNAc cycling: implications for neurodegenerative disorders
BD Lazarus, DC Love, JA Hanover - … journal of biochemistry & cell biology, 2009 - Elsevier
The dynamic post-translational modification of proteins by O-linked N-acetylglucosamine (O-
GlcNAc), termed O-GlcNAcylation, is an important mechanism for modulating cellular …
GlcNAc), termed O-GlcNAcylation, is an important mechanism for modulating cellular …
Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)–processing enzymes
The post-translational modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc)
dynamically programmes cellular physiology to maintain homoeostasis and tailor …
dynamically programmes cellular physiology to maintain homoeostasis and tailor …
Demystifying the O-GlcNAc code: a systems view
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …
O-GlcNAc as an integrator of signaling pathways
O-GlcNAcylation is an important posttranslational modification governed by a single pair of
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
enzymes–O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes …
[HTML][HTML] Growing and dividing: how O-GlcNAcylation leads the way
Cell cycle errors can lead to mutations, chromosomal instability, or death; thus, the precise
control of cell cycle progression is essential for viability. The nutrient-sensing post …
control of cell cycle progression is essential for viability. The nutrient-sensing post …
Targeting O-GlcNAcylation to develop novel therapeutics
Y Zhu, GW Hart - Molecular aspects of medicine, 2021 - Elsevier
O-linked β-DN-acetylglucosamine (O-GlcNAc) is an abundant post-translational modification
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
(PTM) that modifies the serine or threonine residues of thousands of proteins in the nucleus …
Stress-induced O-GlcNAcylation: an adaptive process of injured cells
MR Martinez, TB Dias, PS Natov… - Biochemical Society …, 2017 - portlandpress.com
In the 30 years, since the discovery of nucleocytoplasmic glycosylation, O-GlcNAc has been
implicated in regulating cellular processes as diverse as protein folding, localization …
implicated in regulating cellular processes as diverse as protein folding, localization …