Aims Voriconazole is a new triazole antifungal agent, and is metabolized by the cytochrome
P450 isoenzymes CYP2C9, CYP2C19, and, to a lesser extent, by CYP3A4. Phenytoin is an …

ABSTRACT A new selective high-performance liquid chromatography (HPLC) method with
UV detection for the determination of the investigational triazole voriconazole in human …

Background: Reports of resistance and intolerance to currently available antifungal agents
are increasing. Voriconazole is a broad-spectrum azole antifungal agent structurally derived …

An analytical method for the determination of voriconazole (UK-109,496; Pfizer) in plasma
was developed and validated. The method utilizes solid-phase extraction technology and …

Voriconazole is a new antifungal agent that can be given orally and intravenously. It has
proven efficacy for treating candidosis and invasive aspergillosis as well as other mould …

Voriconazole is a potent triazole with broad-spectrum antifungal activity against clinically
significant and emerging pathogens. The present population pharmacokinetic analysis …

In this study, the safety, tolerability, and pharmacokinetics of intravenous (iv)-to oral-dose
regimens of voriconazole were evaluated with a group of 42 healthy men, 41 of whom …

We evaluated the efficacy of voriconazole, a new broad-spectrum triazole antifungal
compound, in the treatment of murine pulmonary blastomycosis. Since mice metabolize …

Voriconazole is both a substrate and a potent inhibitor of cytochrome P450 (CYP) 3A. It has
a high bioavailability and non-linear pharmacokinetics. We investigated the …

Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum
of activity against a variety of yeasts and filamentous fungi. It exhibits fungicidal activity …