Capsaicin has now been shown to have a neurotoxic action on C-fibres in adult rodents and
several other mammalian species. In the adult the effect is preferentially on nociceptive C …

The introduction of capsaicin for studying primary afferent neurons¹² has heralded the
beginning of a new era in sensory pharmacology, 3-8 since for the first time a substance has …

We owe to N. Jancso'and his co-workers the discovery that animals treated with capsaicin
become, after an initial intense excitation of sensory neurons, unresponsive to noxious …

Local application of capsaicin to the sciatic nerve of rats induced a long-lasting increase in
the nociceptive threshold as tested by the hot-plate method, and prevented neurogenic …

Capsaicin activates poorly myelinated primary afferent neurons, many of which are
polymodal nociceptors. Activation is accompanied by membrane depolarization and the …

In the late fifties and sixties Jancso published a series of papers on 'the peculiar
pharmacological effect of capsaicin Capsaicin or 8-methyl-N-vanillyi-6-nonenamide is the …

Over the past several decades capsaicin, a natural product of certain species of red pepper,
has been found to have a broad range of physiological effects in adult animals. Recent …

The intention was to clarify, experimentally, some of the clinical properties of capsaicin. The
modulation of histamine‐induced immediate inflammatory responses following subsequent …

Activation of sensory unmyelinated neurons by noxious stimuli evokes the release of
neuropeptides, such as substance P and calcitonin gene-related peptide (CGRP) from …