Chimeric antigen receptor (CAR) T cell therapy for cancer. Challenges and opportunities: An overview

A Cortes-Hernandez, EK Alvarez-Salazar… - Cancer cell signaling …, 2021 - Springer
The use of immunotherapy as an alternative treatment for cancer patients has become of
great interest in the scientific community as it is required to overcome many of the currently …

[HTML][HTML] CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies

D Sun, X Shi, S Li, X Wang… - Molecular …, 2024 - … .spandidos-publications.com
Chimeric antigen receptor (CAR)‑T cell therapy is an innovative approach to immune cell
therapy that works by modifying the T cells of a patient to express the CAR protein on their …

[HTML][HTML] From hematopoietic stem cell transplantation to chimeric antigen receptor therapy: advances, limitations and future perspectives

E Voynova, D Kovalovsky - Cells, 2021 - mdpi.com
Chimeric antigen receptor (CAR) T-cell therapy was envisioned as a mechanism to re-direct
effector T-cells to eliminate tumor cells. CARs are composed of the variable region of an …

CAR T-cell therapy: Balance of efficacy and safety

SV Kulemzin, VV Kuznetsova, M Mamonkin… - Molecular Biology, 2017 - Springer
Early results from clinical trials of autologous chimeric antigen receptor (CAR)-expressing T
cells for the therapy of B-cell malignancies have encouraged extending the potency of this …

Recent clinical trials utilizing chimeric antigen receptor T cells therapies against solid tumors

S Han, O Latchoumanin, G Wu, G Zhou, L Hebbard… - Cancer letters, 2017 - Elsevier
Chimeric antigen receptors (CARs) are a series of manufactured receptors that have the
capacity of binding to specific antigens expressed on surface of tumor cells. A CAR normally …

CAR-T cell therapy: challenges and optimization

M Luo, H Zhang, L Zhu, Q Xu… - Critical Reviews™ in …, 2021 - dl.begellhouse.com
Immunotherapy has emerged as a potent and effective treatment for multiple cancer types.
For example, the engineering of T cells through the expression of chimeric antigen receptor …

[HTML][HTML] CAR-T cell therapy: current limitations and potential strategies

RC Sterner, RM Sterner - Blood cancer journal, 2021 - nature.com
Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer
treatment. Although treatment with CAR-T cells has produced remarkable clinical responses …

CAR T cell therapy for solid tumors

K Newick, S O'Brien, E Moon… - Annual review of …, 2017 - annualreviews.org
The field of cancer immunotherapy has been re-energized by the application of chimeric
antigen receptor (CAR) T cell therapy in cancers. These CAR T cells are engineered to …

[HTML][HTML] Chimeric-antigen-receptor (CAR) T cells and the factors influencing their therapeutic efficacy

VG Kravets, Y Zhang, H Sun - Journal of immunology research and …, 2017 - ncbi.nlm.nih.gov
Immunotherapeutic treatments for malignant cancers have revolutionized the medical and
scientific fields. Lymphocytes engineered to display chimeric antigen receptor (CAR) …

[HTML][HTML] Innovative strategies to advance CAR T cell therapy for solid tumors

M Huang, J Deng, L Gao, J Zhou - American journal of cancer …, 2020 - ncbi.nlm.nih.gov
Current cancer treatment strategies have been advanced by chimeric antigen receptor
(CAR) cell therapy, a rapidly emerging cellular immunotherapy. The numerous revolutionary …