BackgroundAlthough many studies suggest that, on average, depression-specific
psychotherapy and antidepressant pharmacotherapy are efficacious, we know relatively little …

Background: Despite the availability of many effective treatments, patients with major
depression remain at risk for relapse following remission of a depressive episode. The aims …

The objective of this manuscript is to report associations between baseline depressive
severity and (1) baseline sociodemographic and clinical characteristics,(2) treatment …

Background: Although efficacy studies suggest equal potency among antidepressant
treatments, their effectiveness in clinical practice appears more variable, particularly in that …

Patients with Major Depressive Disorder (MDD) may not respond to antidepressants for 8
weeks or longer. A biomarker that predicted treatment effectiveness after only 1 week could …

Background: Few data are available to guide treatment selection in major depression. With
increasing pressure to maximize the efficiency and minimize the costs of treatment, it is …

Depression is the fourth-largest contributor to the global burden of disease, and it causes
profound suffering and extreme costs to health care systems and society. Although there …

OBJECTIVE: To investigate whether subtypes of depression predict differential outcomes of
treatment with selective serotonin-reuptake inhibitor (SSRI) and a tricyclic antidepressant in …

Prior analyses of data from the NIMH sponsored Treatment for Depression Collaborative
Research Program (TDCRP; eg, Elkin, 1994) indicated greater reduction of symptoms at …

Background: Few reliable correlates of treatment response in depression have emerged
despite nearly 40 years of research. We examined the correlates of recovery in a" mega …