Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
[HTML][HTML] Role of DNA methylation in modulating transcription factor occupancy
MT Maurano, H Wang, S John, A Shafer, T Canfield… - Cell reports, 2015 - cell.com
Although DNA methylation is commonly invoked as a mechanism for transcriptional
repression, the extent to which it actively silences transcription factor (TF) occupancy sites in …
repression, the extent to which it actively silences transcription factor (TF) occupancy sites in …
[HTML][HTML] The human transcription factors
Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …
transcription, forming a complex system that guides expression of the genome. Despite keen …
[HTML][HTML] Bidirectional transcription arises from two distinct hubs of transcription factor binding and active chromatin
BS Scruggs, DA Gilchrist, S Nechaev, GW Muse… - Molecular cell, 2015 - cell.com
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-
documented phenomenon, but remarkably little is known about the regulation or function of …
documented phenomenon, but remarkably little is known about the regulation or function of …
[HTML][HTML] Absence of a simple code: how transcription factors read the genome
Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …
[HTML][HTML] DNase footprint signatures are dictated by factor dynamics and DNA sequence
MH Sung, MJ Guertin, S Baek, GL Hager - Molecular cell, 2014 - cell.com
Genomic footprinting has emerged as an unbiased discovery method for transcription factor
(TF) occupancy at cognate DNA in vivo. A basic premise of footprinting is that sequence …
(TF) occupancy at cognate DNA in vivo. A basic premise of footprinting is that sequence …
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
The current knowledge on how transcription factors (TF s), the ultimate targets and executors
of cellular signalling pathways, are regulated by protein–protein interactions remains limited …
of cellular signalling pathways, are regulated by protein–protein interactions remains limited …
[HTML][HTML] The functional consequences of variation in transcription factor binding
One goal of human genetics is to understand how the information for precise and dynamic
gene expression programs is encoded in the genome. The interactions of transcription …
gene expression programs is encoded in the genome. The interactions of transcription …
Disentangling the many layers of eukaryotic transcriptional regulation
KM Lelli, M Slattery, RS Mann - Annual review of genetics, 2012 - annualreviews.org
Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …
review, we break down several critical steps, emphasizing new data and techniques that …
Mechanisms by which transcription factors gain access to target sequence elements in chromatin
MJ Guertin, JT Lis - Current opinion in genetics & development, 2013 - Elsevier
Transcription factors (TF) bind DNA sequence motifs, but the presence of a consensus DNA
element is not sufficient to direct TF binding to chromatin. Recent genomic data have …
element is not sufficient to direct TF binding to chromatin. Recent genomic data have …