Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care
due to their excellent safety profiles and their activity against a wide spectrum of pathogens …

Critically ill patients have increased variability in beta-lactam antibiotic (beta-lactam)
exposure due to alterations in their volume of distribution and elimination. Therapeutic drug …

Background: With increasing knowledge of beta-lactam pharmacodynamics and interpatient
and intrapatient variability in pharmacokinetics, the usefulness of therapeutic drug …

Introduction Individualizing antibiotic therapy is paramount to improve clinical outcomes
while minimizing the risk of toxicity and antimicrobial therapy. β-lactam antibiotics are …

Beta-lactams (BL) are the first line agents for the antibiotic management of critically ill
patients with sepsis or septic shock. BL are hydrophilic antibiotics particularly subject to …

The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly
altered due to the dynamic, unpredictable pathophysiological changes that occur in critical …

Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address
the variability in exposure observed in critical illness. However, the impact of TDM-guided …

OBJECTIVE: β-lactams are the cornerstone of empiric and targeted antibiotic therapy for
critically ill patients. Recently, there have been calls to use β-lactam therapeutic drug …

The extreme pharmacokinetic behaviour of drugs sometimes observed in critically ill patients
poses a significant threat to the achievement of optimal antibiotic treatment outcomes. Scant …

Introduction Antibiotics are commonly prescribed in critical care, and given the large
variability of pharmacokinetic (PK) parameters in these patients, drug PK frequently varies …