DAMPening inflammation by modulating TLR signalling

AM Piccinini, KS Midwood - Mediators of inflammation, 2010 - Wiley Online Library
Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

The role of TLRs in neutrophil activation

LR Prince, MK Whyte, I Sabroe, LC Parker - Current opinion in …, 2011 - Elsevier
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function is …

Danger-associated molecular patterns derived from the extracellular matrix provide temporal control of innate immunity

CW Frevert, J Felgenhauer… - … of Histochemistry & …, 2018 - journals.sagepub.com
It is evident that components of the extracellular matrix (ECM) act as danger-associated
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

FG Goh, KS Midwood - Rheumatology, 2012 - academic.oup.com
RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

[HTML][HTML] DAMPs from cell death to new life

E Vénéreau, C Ceriotti, ME Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways

PJ Murray, ST Smale - Nature immunology, 2012 - nature.com
Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products
drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of …

DAMPs as mediators of sterile inflammation in aging-related pathologies

N Feldman, A Rotter-Maskowitz, E Okun - Ageing research reviews, 2015 - Elsevier
Accumulating evidence indicates that aging is associated with a chronic low-level
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …

DAMPs and DAMP-sensing receptors in inflammation and diseases

M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

T Gong, L Liu, W Jiang, R Zhou - Nature Reviews Immunology, 2020 - nature.com
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …

Toll-like receptor signaling in burn wound healing and scarring

P D'Arpa, KP Leung - Advances in wound care, 2017 - liebertpub.com
Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated
molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic …