DAMPening inflammation by modulating TLR signalling
AM Piccinini, KS Midwood - Mediators of inflammation, 2010 - Wiley Online Library
Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …
The role of TLRs in neutrophil activation
Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function is …
and inflammation to provide early defence against invading microorganisms. This function is …
Danger-associated molecular patterns derived from the extracellular matrix provide temporal control of innate immunity
CW Frevert, J Felgenhauer… - … of Histochemistry & …, 2018 - journals.sagepub.com
It is evident that components of the extracellular matrix (ECM) act as danger-associated
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …
molecular patterns (DAMPs) through direct interactions with pattern recognition receptors …
Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
FG Goh, KS Midwood - Rheumatology, 2012 - academic.oup.com
RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …
inflammation leading to progressive joint destruction. Recent advances in the molecular …
[HTML][HTML] DAMPs from cell death to new life
E Vénéreau, C Ceriotti, ME Bianchi - Frontiers in immunology, 2015 - frontiersin.org
Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …
intracellular molecules released by injured tissues [damage-associated molecular patterns …
Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways
PJ Murray, ST Smale - Nature immunology, 2012 - nature.com
Activation of Toll-like receptor (TLR) signaling and related pathways by microbial products
drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of …
drives inflammatory responses, host-defense pathways and adaptive immunity. The cost of …
DAMPs as mediators of sterile inflammation in aging-related pathologies
N Feldman, A Rotter-Maskowitz, E Okun - Ageing research reviews, 2015 - Elsevier
Accumulating evidence indicates that aging is associated with a chronic low-level
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …
inflammation, termed sterile-inflammation. Sterile-inflammation is a form of pathogen-free …
DAMPs and DAMP-sensing receptors in inflammation and diseases
M Ma, W Jiang, R Zhou - Immunity, 2024 - cell.com
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules
produced in cellular damage or stress, and they can activate the innate immune system …
produced in cellular damage or stress, and they can activate the innate immune system …
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
The innate immune system has the capacity to detect 'non-self'molecules derived from
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
pathogens, known as pathogen-associated molecular patterns, via pattern recognition …
Toll-like receptor signaling in burn wound healing and scarring
P D'Arpa, KP Leung - Advances in wound care, 2017 - liebertpub.com
Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated
molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic …
molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic …