Serotonin 5-HT 4 receptors were first described in mouse colliculi neurons. They are
positively coupled to adenylyl cyclase, and possess unique pharmacological properties …

Reviews the literature on the specific serotonin receptor, the 5-hydroxytryptamine₃ (5-HT₃)
receptor, including the development of selective drugs active at the 5-HT₃ receptor, 5-HT₃ …

Activation of the 5-HT 4 receptor mediates widespread effects in central and peripheral
nervous systems. Recent developments, such as the identification of novel, selective …

Radioligand binding as well as molecular biological studies revealed an hetereogeneity of
serotonin (5-HT) receptors in the central nervous system. The early availability of specific …

The 5-HT3 receptor is unique among known monoamine receptors in that, rather than being
a G-protein-coupled receptor, it forms a ligand-gated ion channel. In the CNS, this receptor …

When first reviewed in TiPS in October 1989', the 5-HT4 receptor had just been
characterized in mammalian brain. It was described as a receptor linked positively to …

Recent reports attributing antiemetic, anxiolytic and antipsychotic properties to selective 5-
HT3 receptor antagonists, combined with the identification by radioligand binding …

Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the
central nervous system, serotonin (5-HT) has been shown to be involved in virtually all …

Among the seven classes of serotonin (5-hydroxytryptamine, 5-HT) receptorswhich have
been identified to date, the 5-HT1 class is comprised of five receptor types, with the 5-HT1A …

5-HT3 receptors or recognition sites have been located in the brain of many animal species
and man, and are considered to mediate an increase in cation conductance. The functional …