[HTML][HTML] Cellular senescence in brain aging
E Sikora, A Bielak-Zmijewska, M Dudkowska… - Frontiers in aging …, 2021 - frontiersin.org
Aging of the brain can manifest itself as a memory and cognitive decline, which has been
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
shown to frequently coincide with changes in the structural plasticity of dendritic spines …
Astrocytes in the aging brain express characteristics of senescence‐associated secretory phenotype
A Salminen, J Ojala, K Kaarniranta… - European Journal of …, 2011 - Wiley Online Library
Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …
triggers several signaling cascades that can induce a condition called cellular senescence …
Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
EOW Gerdes, Y Zhu, BM Weigand, U Tripathi… - International review of …, 2020 - Elsevier
Aging is the major predictor for developing multiple neurodegenerative diseases, including
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …
Alzheimer's disease (AD) other dementias, and Parkinson's disease (PD). Senescent cells …
[HTML][HTML] Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
DJ Baker, RC Petersen - The Journal of clinical …, 2018 - Am Soc Clin Investig
Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …
are inherently associated with increasing age. Age-associated cognitive impairments and …
[HTML][HTML] Cellular senescence in brain aging and neurodegeneration
LSM Dos Santos, M Trombetta-Lima, BJL Eggen… - Ageing Research …, 2023 - Elsevier
Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …
Cell senescence in neuropathology: A focus on neurodegeneration and tumours
G Carreno, R Guiho… - Neuropathology and …, 2021 - Wiley Online Library
The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …
microenvironment through the secretion of a plethora of biologically active products referred …
Cellular senescence in the aging brain: a promising target for neurodegenerative diseases
Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …
biological processes, aging gradually deteriorates overall health. Extensive research on the …
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
M Ogrodnik, SA Evans, E Fielder, S Victorelli… - Aging cell, 2021 - Wiley Online Library
Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …
inflammatory senescence‐associated secretory phenotype (SASP), which is a major …
[HTML][HTML] Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease
JR Herdy, L Traxler, RK Agarwal, L Karbacher… - Cell Stem Cell, 2022 - cell.com
The concept of senescence as a phenomenon limited to proliferating cells has been
challenged by growing evidence of senescence-like features in terminally differentiated …
challenged by growing evidence of senescence-like features in terminally differentiated …
[HTML][HTML] Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy
D Moreno-Blas, E Gorostieta-Salas… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Senescent cells accumulate in various tissues and organs with aging altering surrounding
tissue due to an active secretome, and at least in mice their elimination extends healthy …
tissue due to an active secretome, and at least in mice their elimination extends healthy …
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