Signal transduction cascades induced by mitogenic stimuli directly drive the modification of
preexisting pools of cellular proteins, including transcription factors. Interestingly, multiple …

Transcriptional regulation in mammalian cells is driven by a complex interplay of multiple
transcription factors that respond to signals from either external or internal stimuli. A single …

Cell cycle progression is controlled by signaling pathways that direct the biochemical
changes cells undergo in preparation for DNA replication and subsequent cell division …

LSF (late SV40 factor) is a mammalian transcription factor that regulates expression of both
viral genomes and cellular genes, including that encoding thymidylate synthase, a critical …

Ig heavy chain class switch recombination (CSR) determines the expression of Ig isotypes.
The molecular mechanism of CSR and the factors regulating this process have remained …

Late SV40 factor (LSF) is a CP2 family transcription factor involved in cell cycle regulation. In
liver cancer, LSF is an oncogene, in part due to its role in upregulation of osteopontin …

The HeLa transcription factor LSF has been purified by heparin-agarose and DNA affinity
chromatography, and its DNA binding and transcription properties have been characterized …

Understanding the mechanism by which transcription initiation occurs requires knowledge of
the proteins that bind specific DNA sequences to regulate gene expression. The simian virus …

Transcription from the SV40 late promoter is delayed until the late phase of infection after
viral DNA replication has commenced. Wiley et al.(Genes Dev. 7: 1993) have purified from …

Cis-regions and trans-factors controllingTCL1 oncogene expression are not known. We
identified the functional TCL1 promoter by mapping four transcriptional start sites 24–30 bp …